Evolutionary turnover of key amino acids explains conservation of function without conservation of sequence in transcriptional activation domains

• Claire J. LeBlanc,

  Roles Formal analysis, Methodology, Writing – original draft, Writing – review & editing

  Affiliations Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California, United States of America, Center for Computational Biology, University of California Berkeley, Berkeley, California, United States of America

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• Jordan Stefani,

  Roles Formal analysis, Investigation

  Affiliations Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California, United States of America, Center for Computational Biology, University of California Berkeley, Berkeley, California, United States of America

  https://orcid.org/0000-0002-2130-536X

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• Melvin Soriano,

  Roles Formal analysis, Investigation

  Affiliations Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California, United States of America, Center for Computational Biology, University of California Berkeley, Berkeley, California, United States of America

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• Angelica W. Y. Lam,

  Roles Formal analysis

  Affiliations Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California, United States of America, Center for Computational Biology, University of California Berkeley, Berkeley, California, United States of America

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• Marissa A. Zintel,

  Roles Formal analysis

  Affiliation Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California, United States of America

  https://orcid.org/0009-0008-4670-5272

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• Sanjana R. Kotha,

  Roles Formal analysis

  Affiliations Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California, United States of America, Center for Computational Biology, University of California Berkeley, Berkeley, California, United States of America

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• Emily P. Chase,

  Roles Formal analysis

  Affiliations Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California, United States of America, Center for Computational Biology, University of California Berkeley, Berkeley, California, United States of America

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• Giovani Pimentel-Solorio,

  Roles Formal analysis

  Current address: University of California Davis, Davis, California, United States of America

  Affiliations Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California, United States of America, Center for Computational Biology, University of California Berkeley, Berkeley, California, United States of America

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• Aditya Vunnum,

  Roles Formal analysis

  Affiliation Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California, United States of America

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• Gean Hu,

  Roles Formal analysis

  Affiliation Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California, United States of America

  https://orcid.org/0009-0006-8705-6411

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• Katherine L. Flug,

  Roles Investigation

  Affiliation Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California, United States of America

  https://orcid.org/0009-0009-8504-6502

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• Aaron Fultineer,

  Roles Formal analysis

  Affiliation Department of Physics, University of California Berkeley, Berkeley, California, United States of America

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• Niklas Hummel,

  Roles Formal analysis, Writing – original draft

  Affiliation Department of Biology, Technische Universität Darmstadt, Darmstadt, Germany

  https://orcid.org/0000-0001-7202-2784

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• Max V. Staller

  Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: mstaller@berkeley.edu

  Affiliations Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California, United States of America, Center for Computational Biology, University of California Berkeley, Berkeley, California, United States of America, Chan Zuckerberg Biohub–San Francisco, San Francisco, California, United States of America

  https://orcid.org/0000-0001-9094-5697

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