Polygenic risk scores and Parkinson’s disease in South Africa advancing ancestry informed disease prediction

• Kathryn Step,

  Roles Conceptualization, Formal analysis, Methodology, Project administration, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa, South African Medical Research Council Centre for Tuberculosis Research, Stellenbosch University, Cape Town, South Africa

  https://orcid.org/0000-0002-4054-7030

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• Carene Anne Alene Ndong Sima,

  Roles Methodology, Writing – review & editing

  Affiliations Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa, South African Medical Research Council Centre for Tuberculosis Research, Stellenbosch University, Cape Town, South Africa

  https://orcid.org/0000-0002-8226-6288

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• Spencer Grant,

  Roles Methodology, Writing – review & editing

  Affiliations Center for Alzheimer’s and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America, Department of Clinical Neurosciences, School of Clinical Medicine, The University of Cambridge, Cambridge, United Kingdom

  https://orcid.org/0000-0002-7278-0347

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• Jonggeol Jeffrey Kim,

  Roles Methodology, Writing – review & editing

  Affiliation Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

  https://orcid.org/0000-0003-0738-0512

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• Emily Waldo,

  Roles Formal analysis, Writing – review & editing

  Affiliation Genomic Medicine, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio, United States of America

  https://orcid.org/0009-0009-1485-3710

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• Soraya Bardien,

  Roles Conceptualization, Project administration, Supervision, Writing – review & editing

  Affiliations Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa, South African Medical Research Council Centre for Tuberculosis Research, Stellenbosch University, Cape Town, South Africa, South African Medical Research Council/Stellenbosch University Genomics of Brain Disorders Research Unit, Stellenbosch University, Cape Town, South Africa

  https://orcid.org/0000-0002-3508-3438

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• Ignacio F. Mata ,

  Roles Conceptualization, Project administration, Supervision, Writing – review & editing

  ^* MATAI@ccf.org

  Affiliation Genomic Medicine, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio, United States of America

  https://orcid.org/0000-0003-1198-0633

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• on behalf of the Global Parkinson’s Genetics Program (GP2)

  ¶Membership of Global Parkinson’s Genetics Program (GP2) is provided in S4 Table and at https://doi.org/10.5281/zenodo.7904831.

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