Metabolic and behavioral effects of neurofibromin result from differential recruitment of MAPK and mTOR signaling

Valentina Botero; Jenifer Barrios; Anneke Knauss; Greta Dahlen; Ethan Rosendahl; Kenneth J. Colodner; Seth M. Tomchik

doi:10.1371/journal.pgen.1012061

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Open Access

Peer-reviewed

Research Article

Metabolic and behavioral effects of neurofibromin result from differential recruitment of MAPK and mTOR signaling

Valentina Botero,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

Affiliation Neuroscience and Pharmacology, University of Iowa, Iowa City, Iowa, United States of America

https://orcid.org/0000-0002-9744-3929

⨯
Jenifer Barrios,

Roles Formal analysis, Investigation, Writing – review & editing

Affiliation Neuroscience and Pharmacology, University of Iowa, Iowa City, Iowa, United States of America
⨯
Anneke Knauss,

Roles Formal analysis, Investigation, Visualization, Writing – review & editing

Affiliation Neuroscience and Pharmacology, University of Iowa, Iowa City, Iowa, United States of America

https://orcid.org/0000-0001-5026-5064

⨯
Greta Dahlen,

Roles Formal analysis, Investigation, Visualization, Writing – review & editing

Affiliation Neuroscience and Pharmacology, University of Iowa, Iowa City, Iowa, United States of America
⨯
Ethan Rosendahl,

Roles Investigation, Visualization, Writing – review & editing

Affiliation Neuroscience and Pharmacology, University of Iowa, Iowa City, Iowa, United States of America

https://orcid.org/0009-0000-2894-5303

⨯
Kenneth J. Colodner,

Roles Investigation, Writing – review & editing

Affiliation Program in Neuroscience and Behavior, Mount Holyoke College, South Hadley, Massachusetts, United States of America

https://orcid.org/0000-0003-1830-3483

⨯
Seth M. Tomchik

Roles Conceptualization, Funding acquisition, Methodology, Resources, Supervision, Writing – original draft, Writing – review & editing

* E-mail: seth-tomchik@uiowa.edu

Affiliations Neuroscience and Pharmacology, University of Iowa, Iowa City, Iowa, United States of America, Stead Family Department of Pediatrics, University of Iowa, Iowa City, Iowa, United States of America, Iowa Neuroscience Institute, University of Iowa, Iowa City, Iowa, United States of America, FOE Diabetes Research Center, University of Iowa, Iowa City, Iowa, United States of America

https://orcid.org/0000-0001-5686-0833

⨯

Metabolic and behavioral effects of neurofibromin result from differential recruitment of MAPK and mTOR signaling

Valentina Botero,
Jenifer Barrios,
Anneke Knauss,
Greta Dahlen,
Ethan Rosendahl,
Kenneth J. Colodner,
Seth M. Tomchik

Published: March 5, 2026
https://doi.org/10.1371/journal.pgen.1012061

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Neurofibromatosis type 1
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MAPK signaling cascades
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Mitochondria
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Ras signaling
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Behavior
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RNA interference
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Neurons
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Drosophila melanogaster
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