The RPA-binding domain and the KKRK motif in Rad26ATRIP cooperate at the perturbed DNA replication fork for initiating checkpoint signalling

Yong-jie Xu; Anmin Gao; Kamal Dev; Yuyuan Zheng; Mashael Y. Alyahya; Sairam Pasam; Guramrit Kaur; Chun Zhou

doi:10.1371/journal.pgen.1012052

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Open Access

Peer-reviewed

Research Article

The RPA-binding domain and the KKRK motif in Rad26^ATRIP cooperate at the perturbed DNA replication fork for initiating checkpoint signalling

Yong-jie Xu ,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

* E-mail: yong-jie.xu@wright.edu

Affiliation Department of Pharmacology and Toxicology, Boonshoft School of Medicine, Wright State University, Dayton, Ohio, United States of America

https://orcid.org/0000-0002-5091-5247

⨯
Anmin Gao,

Roles Data curation, Investigation

Affiliation School of Public Health and Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China
⨯
Kamal Dev,

Roles Data curation, Formal analysis, Investigation

Affiliation Department of Pharmacology and Toxicology, Boonshoft School of Medicine, Wright State University, Dayton, Ohio, United States of America
⨯
Yuyuan Zheng,

Roles Data curation, Formal analysis, Investigation

Affiliation School of Public Health and Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China
⨯
Mashael Y. Alyahya,

Roles Data curation, Investigation

Affiliation Department of Pharmacology and Toxicology, Boonshoft School of Medicine, Wright State University, Dayton, Ohio, United States of America
⨯
Sairam Pasam,

Roles Investigation

Affiliation Department of Pharmacology and Toxicology, Boonshoft School of Medicine, Wright State University, Dayton, Ohio, United States of America
⨯
Guramrit Kaur,

Roles Investigation

Affiliation Department of Pharmacology and Toxicology, Boonshoft School of Medicine, Wright State University, Dayton, Ohio, United States of America

https://orcid.org/0009-0002-9110-654X

⨯
Chun Zhou

Roles Data curation, Funding acquisition, Investigation, Project administration, Supervision, Writing – review & editing

Affiliation School of Public Health and Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China
⨯

The RPA-binding domain and the KKRK motif in Rad26^ATRIP cooperate at the perturbed DNA replication fork for initiating checkpoint signalling

Yong-jie Xu,
Anmin Gao,
Kamal Dev,
Yuyuan Zheng,
Mashael Y. Alyahya,
Sairam Pasam,
Guramrit Kaur,
Chun Zhou

Published: February 23, 2026
https://doi.org/10.1371/journal.pgen.1012052

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Phosphorylation
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DNA damage
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Recombinase polymerase amplification
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Schizosaccharomyces pombe
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Saccharomyces cerevisiae
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DNA replication
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Protein kinase signaling cascade
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Signal initiation
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