An ArfGAP-dependent signaling modulates synaptic plasticity via IP3-regulated calcium release from the endoplasmic reticulum

Bhagaban Mallik; Shikha Kushwaha; Anjali Bisht; Harsha MJ; C Andrew Frank; Vimlesh Kumar

doi:10.1371/journal.pgen.1012031

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Open Access

Peer-reviewed

Research Article

An ArfGAP-dependent signaling modulates synaptic plasticity via IP3-regulated calcium release from the endoplasmic reticulum

Bhagaban Mallik,

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations Department of Biological Sciences, Indian Institute of Science Education and Research (IISER) Bhopal, Bhopal, Madhya Pradesh, India, Department of Anatomy and Cell Biology, University of Iowa, Lowa City, Iowa, United States of America
⨯
Shikha Kushwaha,

Roles Investigation, Visualization

Affiliation Department of Biological Sciences, Indian Institute of Science Education and Research (IISER) Bhopal, Bhopal, Madhya Pradesh, India
⨯
Anjali Bisht,

Roles Investigation, Validation, Visualization

Affiliation Department of Biological Sciences, Indian Institute of Science Education and Research (IISER) Bhopal, Bhopal, Madhya Pradesh, India
⨯
Harsha MJ,

Roles Investigation, Visualization, Writing – review & editing

Affiliation Department of Biological Sciences, Indian Institute of Science Education and Research (IISER) Bhopal, Bhopal, Madhya Pradesh, India

https://orcid.org/0000-0002-6481-0665

⨯
C Andrew Frank ,

Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Supervision, Writing – review & editing

* E-mail: andy-frank@uiowa.edu (CAF); vimlesh@iiserb.ac.in (VK)

Affiliation Department of Anatomy and Cell Biology, University of Iowa, Lowa City, Iowa, United States of America

https://orcid.org/0000-0001-9599-421X

⨯
Vimlesh Kumar

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: andy-frank@uiowa.edu (CAF); vimlesh@iiserb.ac.in (VK)

Affiliation Department of Biological Sciences, Indian Institute of Science Education and Research (IISER) Bhopal, Bhopal, Madhya Pradesh, India

https://orcid.org/0000-0003-2206-4905

⨯

An ArfGAP-dependent signaling modulates synaptic plasticity via IP3-regulated calcium release from the endoplasmic reticulum

Bhagaban Mallik,
Shikha Kushwaha,
Anjali Bisht,
Harsha MJ,
C Andrew Frank,
Vimlesh Kumar

Published: January 23, 2026
https://doi.org/10.1371/journal.pgen.1012031

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