Genomic profiling of active vitamin D colonic responses in African- and European-Americans identifies an ancestry-related regulatory variant of POLB

David Witonsky; Bharathi Laxman; Hina Usman; Margaret C. Bielski; Kristi M. Lawrence; Sonia S. Kupfer

doi:10.1371/journal.pgen.1011983

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Peer-reviewed

Research Article

Genomic profiling of active vitamin D colonic responses in African- and European-Americans identifies an ancestry-related regulatory variant of POLB

David Witonsky ,

Contributed equally to this work with: David Witonsky, Bharathi Laxman

Roles Conceptualization, Data curation, Formal analysis, Methodology, Writing – original draft, Writing – review & editing

Affiliation Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America

https://orcid.org/0000-0002-3274-9003

⨯
Bharathi Laxman ,

Contributed equally to this work with: David Witonsky, Bharathi Laxman

Roles Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliation Section of Gastroenterology, Hepatology & Nutrition, Department of Medicine, University of Chicago, Chicago, Illinois, United States of America
⨯
Hina Usman,

Roles Methodology

Affiliation Section of Gastroenterology, Hepatology & Nutrition, Department of Medicine, University of Chicago, Chicago, Illinois, United States of America

https://orcid.org/0009-0003-0569-7361

⨯
Margaret C. Bielski,

Roles Investigation, Methodology

Affiliation Section of Gastroenterology, Hepatology & Nutrition, Department of Medicine, University of Chicago, Chicago, Illinois, United States of America
⨯
Kristi M. Lawrence,

Roles Investigation

Affiliation Section of Gastroenterology, Hepatology & Nutrition, Department of Medicine, University of Chicago, Chicago, Illinois, United States of America

https://orcid.org/0009-0000-0998-9204

⨯
Sonia S. Kupfer

Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: skupfer@medicine.bsd.uchicago.edu

Affiliations Section of Gastroenterology, Hepatology & Nutrition, Department of Medicine, University of Chicago, Chicago, Illinois, United States of America, Section of Genetic Medicine, Department of Medicine, University of Chicago, Chicago, Illinois, United States of America
⨯

Genomic profiling of active vitamin D colonic responses in African- and European-Americans identifies an ancestry-related regulatory variant of POLB

David Witonsky,
Bharathi Laxman,
Hina Usman,
Margaret C. Bielski,
Kristi M. Lawrence,
Sonia S. Kupfer

Published: January 8, 2026
https://doi.org/10.1371/journal.pgen.1011983

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Vitamin D
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Organoids
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Chromatin
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Colon
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Homozygosity
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Gene regulation
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