The Drosophila G protein-coupled receptor, GulpR, is essential for lipid mobilization in response to nutrient-limitation

Daniela Barraza; Xiang Ding; Lauren Findley; Zihuan Wang; Bat-Erdene Jugder; Paula I. Watnick

doi:10.1371/journal.pgen.1011982

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Peer-reviewed

Research Article

The Drosophila G protein-coupled receptor, GulpR, is essential for lipid mobilization in response to nutrient-limitation

Daniela Barraza ,

Contributed equally to this work with: Daniela Barraza, Xiang Ding

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Writing – original draft, Writing – review & editing

Affiliations Division of Infectious Diseases, Boston Children’s Hospital, Boston, Massachusetts, United States of America, Biological and Biomedical Sciences Program, Harvard Medical School, Boston, Massachusetts, United States of America

https://orcid.org/0000-0002-6719-6197

⨯
Xiang Ding ,

Contributed equally to this work with: Daniela Barraza, Xiang Ding

Roles Conceptualization, Formal analysis, Investigation, Supervision, Writing – review & editing

Affiliations Division of Infectious Diseases, Boston Children’s Hospital, Boston, Massachusetts, United States of America, Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Lauren Findley,

Roles Investigation

Affiliation Division of Infectious Diseases, Boston Children’s Hospital, Boston, Massachusetts, United States of America

https://orcid.org/0009-0007-0925-9560

⨯
Zihuan Wang,

Roles Investigation

Affiliation Division of Infectious Diseases, Boston Children’s Hospital, Boston, Massachusetts, United States of America
⨯
Bat-Erdene Jugder,

Roles Investigation

Affiliations Division of Infectious Diseases, Boston Children’s Hospital, Boston, Massachusetts, United States of America, Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, United States of America

https://orcid.org/0000-0002-8893-1170

⨯
Paula I. Watnick

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Supervision, Writing – original draft, Writing – review & editing

* E-mail: paula.watnick@childrens.harvard.edu

Affiliations Division of Infectious Diseases, Boston Children’s Hospital, Boston, Massachusetts, United States of America, Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, United States of America

https://orcid.org/0000-0002-9173-8662

⨯

The Drosophila G protein-coupled receptor, GulpR, is essential for lipid mobilization in response to nutrient-limitation

Daniela Barraza,
Xiang Ding,
Lauren Findley,
Zihuan Wang,
Bat-Erdene Jugder,
Paula I. Watnick

Published: December 12, 2025
https://doi.org/10.1371/journal.pgen.1011982

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Gastrointestinal tract
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Lipids
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Drosophila melanogaster
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Vibrio cholerae
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G protein coupled receptors
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Gene regulation
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