Targeting and anchoring the mechanosensitive ion channel Piezo to facilitate its inhibition of axon regeneration

• Qin Wang ,

  Contributed equally to this work with: Qin Wang, Leanne Miles, Shuo Wang, Lilly M. Ryll

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliations Raymond G. Perelman Center for Cellular and Molecular Therapeutics, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

  ⨯
• Leanne Miles ,

  Contributed equally to this work with: Qin Wang, Leanne Miles, Shuo Wang, Lilly M. Ryll

  Roles Conceptualization, Investigation, Methodology, Writing – review & editing

  Affiliation The Graduate Group in Biochemistry and Molecular Biophysics, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

  ⨯
• Shuo Wang ,

  Contributed equally to this work with: Qin Wang, Leanne Miles, Shuo Wang, Lilly M. Ryll

  Roles Investigation

  Affiliations Center for Neural Development and Repair, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, United States of America, Department of Neural Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, United States of America

  ⨯
• Lilly M. Ryll ,

  Contributed equally to this work with: Qin Wang, Leanne Miles, Shuo Wang, Lilly M. Ryll

  Roles Formal analysis, Funding acquisition, Investigation, Writing – review & editing

  Affiliation The Neuroscience Graduate Group, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

  https://orcid.org/0009-0005-4247-3580

  ⨯
• Harun N. Noristani,

  Roles Investigation

  Affiliations Center for Neural Development and Repair, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, United States of America, Department of Neural Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, United States of America

  ⨯
• Ethan Schauer,

  Roles Investigation, Methodology

  Affiliation Pediatrics, University of California, San Diego, La Jolla, California, United States of America

  https://orcid.org/0009-0009-2833-7119

  ⨯
• Ernest J. Monahan Vargas,

  Roles Investigation

  Affiliations Raymond G. Perelman Center for Cellular and Molecular Therapeutics, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

  ⨯
• Jackson Powell,

  Roles Writing – review & editing

  Affiliations Raymond G. Perelman Center for Cellular and Molecular Therapeutics, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

  https://orcid.org/0000-0003-4302-1306

  ⨯
• Sean J. O’Rourke-Ibach,

  Roles Investigation

  Affiliations Center for Neural Development and Repair, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, United States of America, Department of Neural Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, United States of America

  ⨯
• Naiara Akizu,

  Roles Supervision

  Affiliations Raymond G. Perelman Center for Cellular and Molecular Therapeutics, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

  ⨯
• Jill Wildonger,

  Roles Investigation, Methodology, Supervision

  Affiliations Pediatrics, University of California, San Diego, La Jolla, California, United States of America, Cell & Developmental Biology, School of Biological Sciences, University of California, San Diego, La Jolla, California, United States of America

  https://orcid.org/0000-0002-6462-5830

  ⨯
• Shuxin Li ,

  Roles Funding acquisition, Investigation, Methodology, Supervision, Writing – review & editing

  * E-mail: shuxin.li@temple.edu (SL); songy2@chop.edu (YS)

  Affiliations Center for Neural Development and Repair, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, United States of America, Department of Neural Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, United States of America

  ⨯
• Yuanquan Song

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: shuxin.li@temple.edu (SL); songy2@chop.edu (YS)

  Affiliations Raymond G. Perelman Center for Cellular and Molecular Therapeutics, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

  https://orcid.org/0000-0001-7699-2059

  ⨯