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Open Access
Peer-reviewed
Research Article
Genetic determinants of zinc homeostasis and its role in cardiometabolic diseases
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Marie C. Sadler ,
Roles Formal analysis, Visualization, Writing – original draft, Writing – review & editing
¶† Joint first authors.
Affiliations Department of Epidemiology and Health Systems (DESS), University Center for General Medicine and Public Health (UNISANTE), Lausanne, Switzerland, Department of Computational Biology, University of Lausanne, Lausanne, Switzerland, Swiss Institute of Bioinformatics, Lausanne, Switzerland
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Jean-Pierre Ghobril ,
Roles Conceptualization, Formal analysis, Visualization, Writing – original draft, Writing – review & editing
¶† Joint first authors.
Affiliation Department of Epidemiology and Health Systems (DESS), University Center for General Medicine and Public Health (UNISANTE), Lausanne, Switzerland
⨯ -
Oleg Borisov ,
Roles Formal analysis, Visualization, Writing – original draft, Writing – review & editing
¶† Joint first authors.
Affiliation Institute of Genetic Epidemiology, Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
⨯ -
Maïwenn Perrais ,
Roles Investigation, Writing – review & editing
¶† Joint first authors.
Affiliations Unit of Forensic Toxicology and Chemistry, CURML, Lausanne and Geneva University Hospitals, Lausanne, Geneva, Switzerland, Faculty Unit of Toxicology, CURML, Lausanne-Geneva, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland
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Guglielmo Schiano ,
Roles Formal analysis, Investigation, Visualization, Writing – original draft, Writing – review & editing
¶† Joint first authors.
Affiliations Institute of Physiology, University of Zurich, Zurich, Switzerland, Functional Genomics Center Zurich, ETH Zurich and University Zurich, Zurich, Switzerland
⨯ - Dusan Petrovic,
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Eunji Ha,
Roles Formal analysis, Writing – review & editing
Affiliation Department of Medicine/Nephrology University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America
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Belén Ponte,
Roles Investigation, Writing – review & editing
Affiliation Department of Nephrology and Hypertension, Geneva University Hospitals (HUG), Geneva, Switzerland
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Yong Li,
Roles Formal analysis, Writing – review & editing
Affiliation Institute of Genetic Epidemiology, Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
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Zulema Rodriguez-Hernandez,
Roles Writing – review & editing
Affiliation Institute of Genetic Epidemiology, Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
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Menno Pruijm,
Roles Investigation, Writing – review & editing
Affiliation Department of Nephrology and Hypertension, Lausanne University Hospital (CHUV), Lausanne, Switzerland
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Daniel Ackermann,
Roles Investigation, Writing – review & editing
Affiliation University Clinic for Nephrology and Hypertension, Bern University Hospital and University of Bern, Bern, Switzerland
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Idris Guessous,
Roles Investigation, Writing – review & editing
Affiliation Department and Division of Primary Care Medicine, Geneva University Hospitals, Geneva, Switzerland
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Silvia Stringhini,
Roles Investigation, Writing – review & editing
Affiliation Department and Division of Primary Care Medicine, Geneva University Hospitals, Geneva, Switzerland
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Georg Ehret,
Roles Investigation, Writing – review & editing
Affiliation Department of Cardiology, Geneva University Hospitals (HUG), Geneva, Switzerland
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Tanguy Corre,
Roles Investigation, Writing – review & editing
Affiliation Department of Epidemiology and Health Systems (DESS), University Center for General Medicine and Public Health (UNISANTE), Lausanne, Switzerland
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Bruno Vogt,
Roles Investigation, Writing – review & editing
Affiliation University Clinic for Nephrology and Hypertension, Bern University Hospital and University of Bern, Bern, Switzerland
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Pierre-Yves Martin,
Roles Investigation, Writing – review & editing
Affiliation Department of Nephrology and Hypertension, Geneva University Hospitals (HUG), Geneva, Switzerland
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Halit Ongen,
Roles Investigation, Writing – review & editing
Affiliation Genetic Medicine and Development, University of Geneva Medical School-CMU, Geneva, Switzerland
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Emmanouil Dermitzakis,
Roles Investigation, Writing – review & editing
Affiliation Genetic Medicine and Development, University of Geneva Medical School-CMU, Geneva, Switzerland
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Janet E. Williams,
Roles Formal analysis, Writing – review & editing
Affiliation Department of Animal, Veterinary and Food Sciences, University of Idaho, Moscow, Idaho, United States of America
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Brenda M. Murdoch,
Roles Writing – review & editing
Affiliation Department of Animal, Veterinary and Food Sciences, University of Idaho, Moscow, Idaho, United States of America
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Michelle K. McGuire,
Roles Funding acquisition, Writing – review & editing
Affiliation Margaret Ritchie School of Family and Consumer Sciences, University of Idaho, Moscow, Idaho, United States of America
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Courtney L. Meehan,
Roles Funding acquisition, Writing – review & editing
Affiliation Department of Anthropology, Washington State University, Pullman, Washington, United States of America
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INSPIRE Consortium ,
¶A list of authors and affiliations for the INSPIRE Consortium is listed in the S1 File.
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Sébastien Lenglet,
Roles Writing – review & editing
Affiliation Unit of Forensic Toxicology and Chemistry, CURML, Lausanne and Geneva University Hospitals, Lausanne, Geneva, Switzerland
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Katalin Susztak,
Roles Conceptualization, Supervision, Writing – review & editing
Affiliation Department of Medicine/Nephrology University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America
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Julien Vaucher ,
Roles Conceptualization, Funding acquisition, Writing – review & editing
¶‡ Joint last authors.
Affiliations Department of Internal Medicine and Specialties, Division of Internal Medicine, Fribourg Hospital and University of Fribourg, Fribourg, Switzerland, Department of Medicine, Division of Internal Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland
⨯ -
Aurélien Thomas ,
Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing
¶‡ Joint last authors.
Affiliations Unit of Forensic Toxicology and Chemistry, CURML, Lausanne and Geneva University Hospitals, Lausanne, Geneva, Switzerland, Faculty Unit of Toxicology, CURML, Lausanne-Geneva, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland
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Olivier Devuyst ,
Roles Conceptualization, Funding acquisition, Resources, Supervision, Writing – original draft, Writing – review & editing
¶‡ Joint last authors.
Affiliation Institute of Physiology, University of Zurich, Zurich, Switzerland
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Anna Köttgen ,
Roles Conceptualization, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing
¶‡ Joint last authors.
Affiliations Institute of Genetic Epidemiology, Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany, Centre for Integrative Biological Signalling Studies, Albert-Ludwigs-Universität Freiburg, Freiburg, Germany
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Murielle Bochud ,
Roles Conceptualization, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing
* E-mail: murielle.bochud@unisante.ch (MB); zoltan.kutalik@unil.ch (ZK)
¶‡ Joint last authors.
Affiliations Department of Epidemiology and Health Systems (DESS), University Center for General Medicine and Public Health (UNISANTE), Lausanne, Switzerland, Department of Medicine, Division of Internal Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland
⨯ - [ ... ],
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Zoltán Kutalik
Roles Conceptualization, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing
* E-mail: murielle.bochud@unisante.ch (MB); zoltan.kutalik@unil.ch (ZK)
¶‡ Joint last authors.
Affiliations Department of Epidemiology and Health Systems (DESS), University Center for General Medicine and Public Health (UNISANTE), Lausanne, Switzerland, Department of Computational Biology, University of Lausanne, Lausanne, Switzerland, Swiss Institute of Bioinformatics, Lausanne, Switzerland
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Genetic determinants of zinc homeostasis and its role in cardiometabolic diseases
- Marie C. Sadler,
- Jean-Pierre Ghobril,
- Oleg Borisov,
- Maïwenn Perrais,
- Guglielmo Schiano,
- Dusan Petrovic,
- Eunji Ha,
- Belén Ponte,
- Yong Li,
- Zulema Rodriguez-Hernandez
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- Published: December 1, 2025
- https://doi.org/10.1371/journal.pgen.1011928