Disruption of the mRNA m6A writer complex triggers autoimmunity in Arabidopsis

Carey L. Metheringham; Anjil K. Srivastava; Peter Thorpe; Ankita Maji; Matthew T. Parker; Geoffrey J. Barton; Gordon G. Simpson

doi:10.1371/journal.pgen.1011925

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Open Access

Peer-reviewed

Research Article

Disruption of the mRNA m⁶A writer complex triggers autoimmunity in Arabidopsis

Carey L. Metheringham ,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Visualization, Writing – original draft, Writing – review & editing

¶☯ Contributed equally

Affiliation School of Life Sciences, University of Dundee, Dundee, United Kingdom

https://orcid.org/0000-0002-5295-694X

⨯
Anjil K. Srivastava ,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing

¶☯ Contributed equally

Affiliation School of Life Sciences, University of Dundee, Dundee, United Kingdom

https://orcid.org/0000-0001-9871-5781

⨯
Peter Thorpe ,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

¶☯ Contributed equally

Affiliation School of Life Sciences, University of Dundee, Dundee, United Kingdom

https://orcid.org/0000-0001-8572-4654

⨯
Ankita Maji,

Roles Formal analysis, Investigation, Visualization, Writing – original draft, Writing – review & editing

Affiliation School of Life Sciences, University of Dundee, Dundee, United Kingdom
⨯
Matthew T. Parker,

Roles Conceptualization, Formal analysis, Investigation, Validation, Visualization, Writing – review & editing

Current Address: Max Planck Institute for Plant Breeding Research, Cologne, Germany.

Affiliation School of Life Sciences, University of Dundee, Dundee, United Kingdom
⨯
Geoffrey J. Barton,

Roles Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

Affiliation School of Life Sciences, University of Dundee, Dundee, United Kingdom

https://orcid.org/0000-0002-9014-5355

⨯
Gordon G. Simpson

Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

* E-mail: g.g.simpson@dundee.ac.uk

Affiliation School of Life Sciences, University of Dundee, Dundee, United Kingdom

https://orcid.org/0000-0001-6744-5889

⨯

Disruption of the mRNA m⁶A writer complex triggers autoimmunity in Arabidopsis

Carey L. Metheringham,
Anjil K. Srivastava,
Peter Thorpe,
Ankita Maji,
Matthew T. Parker,
Geoffrey J. Barton,
Gordon G. Simpson

Published: November 6, 2025
https://doi.org/10.1371/journal.pgen.1011925

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Gene expression
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Arabidopsis thaliana
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Autoimmunity
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Immune response
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Messenger RNA
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RNA sequencing
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