C. elegans SAS-1 ensures centriole integrity and ciliary function, and operates with SSNA-1

Keshav Jha; Alexander Woglar; Coralie Busso; Georgios N. Hatzopoulos; Tatiana Favez; Pierre Gönczy

doi:10.1371/journal.pgen.1011912

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Open Access

Peer-reviewed

Research Article

C. elegans SAS-1 ensures centriole integrity and ciliary function, and operates with SSNA-1

Keshav Jha,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliation Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland

https://orcid.org/0000-0003-2482-6723

⨯
Alexander Woglar,

Roles Conceptualization, Investigation, Supervision, Writing – review & editing

Affiliation Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland
⨯
Coralie Busso,

Roles Investigation

Affiliation Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland
⨯
Georgios N. Hatzopoulos,

Roles Investigation

Affiliation Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland
⨯
Tatiana Favez,

Roles Investigation

Affiliation Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland
⨯
Pierre Gönczy

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing

* E-mail: pierre.gonczy@epfl.ch

Affiliation Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland

https://orcid.org/0000-0002-6305-6883

⨯

C. elegans SAS-1 ensures centriole integrity and ciliary function, and operates with SSNA-1

Keshav Jha,
Alexander Woglar,
Coralie Busso,
Georgios N. Hatzopoulos,
Tatiana Favez,
Pierre Gönczy

Published: October 22, 2025
https://doi.org/10.1371/journal.pgen.1011912

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Centrioles
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Cilia
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Gonads
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Microtubules
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Caenorhabditis elegans
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Immunostaining
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