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Open Access
Peer-reviewed
Research Article
Genetic inference of on-target and off-target side-effects of antipsychotic medications
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Andrew R. Elmore ,
Roles Conceptualization, Data curation, Formal analysis, Investigation, Software, Visualization, Writing – original draft
* E-mail: andrew.elmore@bristol.ac.uk
Affiliations NIHR Bristol Biomedical Research Centre, University Hospitals Bristol and Weston NHS Foundation Trust and University of Bristol, Bristol, United Kingdom, MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Bristol, United Kingdom
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Aws Sadik,
Roles Data curation, Investigation
Affiliations NIHR Bristol Biomedical Research Centre, University Hospitals Bristol and Weston NHS Foundation Trust and University of Bristol, Bristol, United Kingdom, MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Bristol, United Kingdom
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Lavinia Paternoster,
Roles Methodology, Supervision, Writing – review & editing
Affiliations NIHR Bristol Biomedical Research Centre, University Hospitals Bristol and Weston NHS Foundation Trust and University of Bristol, Bristol, United Kingdom, MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Bristol, United Kingdom
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Golam M. Khandaker ,
Roles Conceptualization, Methodology, Supervision, Writing – review & editing
¶‡ Jointly supervised the work.
Affiliations NIHR Bristol Biomedical Research Centre, University Hospitals Bristol and Weston NHS Foundation Trust and University of Bristol, Bristol, United Kingdom, MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Bristol, United Kingdom, Centre for Academic Mental Health, Population Health Sciences, University of Bristol, Bristol, United Kingdom
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Tom R. Gaunt ,
Roles Conceptualization, Methodology, Supervision, Writing – review & editing
¶‡ Jointly supervised the work.
Affiliations NIHR Bristol Biomedical Research Centre, University Hospitals Bristol and Weston NHS Foundation Trust and University of Bristol, Bristol, United Kingdom, MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Bristol, United Kingdom
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Gibran Hemani
Roles Conceptualization, Methodology, Supervision, Writing – review & editing
¶‡ Jointly supervised the work.
Affiliations NIHR Bristol Biomedical Research Centre, University Hospitals Bristol and Weston NHS Foundation Trust and University of Bristol, Bristol, United Kingdom, MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Bristol, United Kingdom
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Genetic inference of on-target and off-target side-effects of antipsychotic medications
- Andrew R. Elmore,
- Aws Sadik,
- Lavinia Paternoster,
- Golam M. Khandaker,
- Tom R. Gaunt,
- Gibran Hemani
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- Published: July 28, 2025
- https://doi.org/10.1371/journal.pgen.1011793