Spatial colocalization and molecular crosstalk of myofibroblastic CAFs and tumor cells shape lymph node metastasis in oral squamous cell carcinoma

• Ken Furudate ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: furudate@hirosaki-u.ac.jp (KF); ktakahashi@mdanderson.org (KT)

  Affiliations Department of Oral and Maxillofacial Surgery, Hirosaki University Graduate School of Medicine, Hirosaki, Japan, Department of Medical Data Intelligence, Research Center for Health-Medical Data Science, Hirosaki University Graduate School of Medicine, Hirosaki, Japan, Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America, Department of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

  https://orcid.org/0000-0003-1272-5490

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• Shuya Kasai,

  Roles Methodology, Resources, Visualization, Writing – review & editing

  Affiliation Department of Stress Response Science, Biomedical Research Center, Hirosaki University Graduate School of Medicine, Hirosaki, Japan

  https://orcid.org/0000-0002-3845-2657

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• Tadashi Yoshizawa,

  Roles Data curation, Formal analysis, Investigation, Methodology, Resources, Validation, Writing – review & editing

  Affiliation Department of Anatomic Pathology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan

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• Yuya Sasaki,

  Roles Funding acquisition, Investigation, Supervision, Writing – review & editing

  Affiliations Department of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America, Department of Hematology, University of Tsukuba Hospital, Tsukuba, Japan

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• Kohei Fujikura,

  Roles Investigation, Supervision, Writing – review & editing

  Affiliation Department of Diagnostic Pathology, Kobe University Graduate School of Medicine, Kobe, Japan

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• Shintaro Goto,

  Roles Resources, Validation, Writing – review & editing

  Affiliation Department of Anatomic Pathology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan

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• Ryohei Ito,

  Roles Conceptualization, Funding acquisition, Investigation, Writing – review & editing

  Affiliation Department of Oral and Maxillofacial Surgery, Hirosaki University Graduate School of Medicine, Hirosaki, Japan

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• Koki Takagi,

  Roles Data curation, Investigation, Resources, Writing – review & editing

  Affiliation Department of Oral and Maxillofacial Surgery, Hirosaki University Graduate School of Medicine, Hirosaki, Japan

  https://orcid.org/0009-0008-5678-0508

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• Tomoyuki Tanaka,

  Roles Validation, Writing – review & editing

  Affiliation Department of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

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• Hiroshi Kijima,

  Roles Resources, Supervision, Validation, Writing – review & editing

  Affiliation Department of Anatomic Pathology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan

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• Kosei Kubota,

  Roles Conceptualization, Investigation, Resources, Writing – review & editing

  Affiliation Department of Oral and Maxillofacial Surgery, Hirosaki University Graduate School of Medicine, Hirosaki, Japan

  https://orcid.org/0000-0003-2408-7545

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• Ken Itoh,

  Roles Resources, Writing – review & editing

  Affiliation Department of Stress Response Science, Biomedical Research Center, Hirosaki University Graduate School of Medicine, Hirosaki, Japan

  https://orcid.org/0000-0002-5518-0729

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• Wataru Kobayashi,

  Roles Conceptualization, Resources, Writing – review & editing

  Affiliation Department of Oral and Maxillofacial Surgery, Hirosaki University Graduate School of Medicine, Hirosaki, Japan

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• Koichi Takahashi

  Roles Conceptualization, Investigation, Project administration, Supervision, Writing – review & editing

  * E-mail: furudate@hirosaki-u.ac.jp (KF); ktakahashi@mdanderson.org (KT)

  Affiliations Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America, Department of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

  https://orcid.org/0000-0002-8027-9659

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