Functional analysis of CYP4B1 enzymes from apes and humans uncovers evolutionary hot spots for adaptations of the catalytical function

• Saskia Hüsken,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft

  Affiliation Department of Otorhinolaryngology, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University, Düsseldorf, Germany

  https://orcid.org/0000-0002-7947-3315

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• Annika Röder,

  Roles Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Institute of Biochemistry, Heinrich-Heine-University, Düsseldorf, Germany

  https://orcid.org/0009-0003-3644-4041

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• Johannes Ptok,

  Roles Formal analysis, Funding acquisition, Writing – review & editing

  Affiliation Institute of Virology, Heinrich-Heine-University, Düsseldorf, Germany

  https://orcid.org/0000-0002-0322-5649

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• Anne E. Meyer,

  Roles Formal analysis, Investigation, Writing – review & editing

  Affiliation Department of Otorhinolaryngology, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University, Düsseldorf, Germany

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• Mats Georg,

  Roles Formal analysis, Investigation, Validation, Writing – review & editing

  Affiliation Institute of Organic Chemistry, Justus Liebig University Giessen, Giessen, Germany

  https://orcid.org/0009-0006-4631-2853

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• Yannick Schwarz,

  Roles Formal analysis, Investigation, Writing – review & editing

  Affiliation Department of Otorhinolaryngology, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University, Düsseldorf, Germany

  https://orcid.org/0009-0005-5559-7582

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• Christian Roos,

  Roles Investigation, Methodology, Validation, Writing – review & editing

  Affiliation German Primate Center, Leibniz Institute for Primate Research, Göttingen, Germany

  https://orcid.org/0000-0003-0190-4266

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• Kerstin Mätz-Rensing,

  Roles Validation, Writing – review & editing

  Affiliation German Primate Center, Leibniz Institute for Primate Research, Göttingen, Germany

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• Michael C. Hutter,

  Roles Investigation, Supervision, Writing – review & editing

  Affiliation Center for Bioinformatics, Saarland University, Saarbrücken, Germany

  https://orcid.org/0000-0003-3168-6554

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• Doreen M. Floss,

  Roles Methodology, Validation, Writing – review & editing

  Affiliation Medical Faculty and University Hospital Düsseldorf, Institute of Biochemistry and Molecular Biology II, Heinrich-Heine-University, Düsseldorf, Germany

  https://orcid.org/0000-0002-6675-5313

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• Allan E. Rettie,

  Roles Validation, Writing – review & editing

  Affiliation Department of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, Washington, United States of America

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• Marco Girhard,

  Roles Funding acquisition, Project administration, Writing – review & editing

  Affiliation Institute of Biochemistry, Heinrich-Heine-University, Düsseldorf, Germany

  https://orcid.org/0000-0002-9054-3628

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• Helmut Hanenberg,

  Roles Conceptualization, Supervision, Validation, Writing – review & editing

  Affiliations Department of Otorhinolaryngology, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University, Düsseldorf, Germany, Department of Pediatrics III, University Children’s Hospital Essen, University Duisburg-Essen, Essen, Germany

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• Constanze Wiek

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Supervision, Validation, Writing – review & editing

  * E-mail: Constanze.wiek@med.uni-duesseldorf.de

  Affiliation Department of Otorhinolaryngology, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University, Düsseldorf, Germany

  https://orcid.org/0000-0003-2214-8148

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