Role of the SAF-A/HNRNPU SAP domain in X chromosome inactivation, nuclear dynamics, transcription, splicing, and cell proliferation

Judith A. Sharp; Emily Sparago; Rachael Thomas; Kaitlyn Alimenti; Wei Wang; Michael D. Blower

doi:10.1371/journal.pgen.1011719

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Open Access

Peer-reviewed

Research Article

Role of the SAF-A/HNRNPU SAP domain in X chromosome inactivation, nuclear dynamics, transcription, splicing, and cell proliferation

Judith A. Sharp,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Resources, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Biochemistry and Cell Biology, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, United States of America

https://orcid.org/0000-0001-7441-6218

⨯
Emily Sparago,

Roles Formal analysis, Investigation, Writing – review & editing

Affiliation Department of Biochemistry and Cell Biology, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, United States of America

https://orcid.org/0000-0003-3780-7345

⨯
Rachael Thomas,

Roles Investigation, Methodology, Visualization, Writing – review & editing

Affiliation Department of Biochemistry and Cell Biology, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, United States of America

https://orcid.org/0000-0002-3373-0910

⨯
Kaitlyn Alimenti,

Roles Investigation, Visualization, Writing – review & editing

Affiliation Department of Biochemistry and Cell Biology, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, United States of America

https://orcid.org/0009-0006-2009-216X

⨯
Wei Wang,

Roles Investigation, Visualization

Affiliation Department of Biochemistry and Cell Biology, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, United States of America

https://orcid.org/0009-0001-8922-8356

⨯
Michael D. Blower

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: mblower@bu.edu

Affiliation Department of Biochemistry and Cell Biology, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, United States of America

https://orcid.org/0000-0002-5037-1972

⨯

Role of the SAF-A/HNRNPU SAP domain in X chromosome inactivation, nuclear dynamics, transcription, splicing, and cell proliferation

Judith A. Sharp,
Emily Sparago,
Rachael Thomas,
Kaitlyn Alimenti,
Wei Wang,
Michael D. Blower

Published: June 10, 2025
https://doi.org/10.1371/journal.pgen.1011719

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Gene expression
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Chromatin
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Small interfering RNA
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RNA splicing
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Serine
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Phosphorylation
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X chromosomes
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RNA structure
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