Reprogramming the EnvZ-OmpR two-component system confers ethanol tolerance in Escherichia coli by stabilizing the outer membrane and altering ferric homeostasis

• Thomas Schalck ,

  Contributed equally to this work with: Thomas Schalck, Meesha Katyal

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft

  Affiliations Centre of Microbial and Plant Genetics (Department of Molecular and Microbial Systems), KU Leuven, Leuven, Belgium, Center for Microbiology, VIB-KU Leuven, Leuven, Belgium

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• Meesha Katyal ,

  Contributed equally to this work with: Thomas Schalck, Meesha Katyal

  Roles Formal analysis, Investigation, Methodology, Visualization, Writing – review & editing

  Affiliations Centre of Microbial and Plant Genetics (Department of Molecular and Microbial Systems), KU Leuven, Leuven, Belgium, Center for Microbiology, VIB-KU Leuven, Leuven, Belgium

  https://orcid.org/0000-0001-9499-0946

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• Sarah De Graeve,

  Roles Formal analysis, Investigation, Methodology

  Affiliations Centre of Microbial and Plant Genetics (Department of Molecular and Microbial Systems), KU Leuven, Leuven, Belgium, Center for Microbiology, VIB-KU Leuven, Leuven, Belgium

  ⨯
• Lars Roba,

  Roles Formal analysis, Investigation, Methodology

  Affiliations Centre of Microbial and Plant Genetics (Department of Molecular and Microbial Systems), KU Leuven, Leuven, Belgium, Center for Microbiology, VIB-KU Leuven, Leuven, Belgium

  ⨯
• Julia Victor Baldoma,

  Roles Formal analysis, Investigation, Methodology

  Affiliations Centre of Microbial and Plant Genetics (Department of Molecular and Microbial Systems), KU Leuven, Leuven, Belgium, Center for Microbiology, VIB-KU Leuven, Leuven, Belgium

  ⨯
• Toon Swings,

  Roles Conceptualization, Methodology, Supervision

  Affiliations Centre of Microbial and Plant Genetics (Department of Molecular and Microbial Systems), KU Leuven, Leuven, Belgium, Center for Microbiology, VIB-KU Leuven, Leuven, Belgium

  https://orcid.org/0000-0002-1225-3377

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• Bram Van den Bergh ,

  Roles Conceptualization, Formal analysis, Methodology, Supervision, Validation, Writing – original draft, Writing – review & editing

  ¶‡ These authors are co-senior authors.

  Affiliations Centre of Microbial and Plant Genetics (Department of Molecular and Microbial Systems), KU Leuven, Leuven, Belgium, Center for Microbiology, VIB-KU Leuven, Leuven, Belgium

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• Jan Michiels

  Roles Conceptualization, Data curation, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: jan.michiels@kuleuven.be

  ¶‡ These authors are co-senior authors.

  Affiliations Centre of Microbial and Plant Genetics (Department of Molecular and Microbial Systems), KU Leuven, Leuven, Belgium, Center for Microbiology, VIB-KU Leuven, Leuven, Belgium

  https://orcid.org/0000-0001-5829-0897

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