Age-associated decline of Coenzyme A leads to intestinal stem cells dysfunction via disturbing iron homeostasis

• Zhiming Liu ,

  Contributed equally to this work with: Zhiming Liu, Gang Du

  Roles Conceptualization, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing

  ¶These authors contributed equally to this work.

  Affiliation West China Centre of Excellence for Pancreatitis, and Laboratory of Metabolism and Aging, Frontiers Science Center for Disease-related Molecular Network, State Key Laboratory of Respiratory Health and Multimorbidity and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China

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• Gang Du ,

  Contributed equally to this work with: Zhiming Liu, Gang Du

  Roles Conceptualization, Investigation, Methodology, Visualization, Writing – review & editing

  ¶These authors contributed equally to this work.

  Affiliations Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America, Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Boston, Massachusetts, United States of America

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• Yi Chen ,

  Roles Conceptualization, Funding acquisition, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: chenhy82@scu.edu.cn (HC); toddy@scu.edu.cn (YC)

  Affiliation Division of Gastrointestinal Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China

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• Haiyang Chen

  Roles Funding acquisition, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: chenhy82@scu.edu.cn (HC); toddy@scu.edu.cn (YC)

  Affiliation West China Centre of Excellence for Pancreatitis, and Laboratory of Metabolism and Aging, Frontiers Science Center for Disease-related Molecular Network, State Key Laboratory of Respiratory Health and Multimorbidity and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China

  https://orcid.org/0000-0001-8305-4060

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