Alzheimer disease is (sometimes) highly heritable: Drivers of variation in heritability estimates for binary traits, a systematic review

• Shiying Liu,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Writing – original draft

  Affiliation Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America

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• William S. Bush,

  Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

  Affiliation Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America

  https://orcid.org/0000-0002-9729-6519

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• Rufus O. Akinyemi,

  Roles Conceptualization, Funding acquisition, Writing – review & editing

  Affiliation Neuroscience and Ageing Research Unit, Institute for Advanced Medical Research and Training, College of Medicine, University of Ibadan, Ibadan, Oyo, Nigeria

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• Goldie S. Byrd,

  Roles Conceptualization, Funding acquisition, Project administration, Writing – review & editing

  Affiliation Maya Angelou Center for Health Equity, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

  https://orcid.org/0000-0003-1057-0261

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• Allison Mercedes Caban-Holt,

  Roles Conceptualization, Investigation, Writing – review & editing

  Affiliation Maya Angelou Center for Health Equity, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America

  https://orcid.org/0000-0001-5393-9116

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• Farid Rajabli,

  Roles Funding acquisition, Writing – review & editing

  Affiliation John P. Hussman Institute for Human Genomics, Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, Florida, United States of America

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• Christiane Reitz,

  Roles Conceptualization, Funding acquisition, Writing – review & editing

  Affiliations Gertrude H. Sergievsky Center, Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Department of Neurology, Columbia University, New York, New York, United States of America, Department of Epidemiology, Columbia University, New York, New York, United States of America

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• Brian W. Kunkle,

  Roles Conceptualization, Funding acquisition, Writing – review & editing

  Affiliation John P. Hussman Institute for Human Genomics, Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, Florida, United States of America

  https://orcid.org/0000-0002-9515-5157

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• Giuseppe Tosto,

  Roles Conceptualization, Funding acquisition, Writing – review & editing

  Affiliations The Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University Irving Medical Center, Columbia University, New York, New York, United States of America, Department of Neurology, Columbia University Irving Medical Center, Columbia University, New York, New York, United States of America, The Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University Irving Medical Center, Columbia University, New York, New York, United States of America

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• Jeffery M. Vance,

  Roles Conceptualization, Funding acquisition, Writing – review & editing

  Affiliations John P. Hussman Institute for Human Genomics, Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, Florida, United States of America, Department of Neurology, University of Miami Miller School of Medicine, Miami, Florida, United States of America

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• Margaret Pericak-Vance,

  Roles Conceptualization, Funding acquisition, Resources, Writing – review & editing

  Affiliation John P. Hussman Institute for Human Genomics, Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, Florida, United States of America

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• Jonathan L. Haines,

  Roles Conceptualization, Data curation, Funding acquisition, Writing – review & editing

  Affiliation Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America

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• Scott M. Williams ,

  Contributed equally to this work with: Scott M. Williams, Dana C. Crawford

  Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Supervision, Writing – review & editing

  * E-mail: smw154@case.edu

  Affiliation Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America

  https://orcid.org/0000-0002-4835-9544

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• Dana C. Crawford

  Contributed equally to this work with: Scott M. Williams, Dana C. Crawford

  Roles Conceptualization, Formal analysis, Investigation, Supervision, Writing – review & editing

  Affiliation Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America

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