Mitochondrial fission surveillance is coupled to Caenorhabditis elegans DNA and chromosome segregation integrity

Xiaomeng Yang; Ruichen Wei; Fanfan Meng; Dianchen Liu; Xuan Gong; Gary Ruvkun; Wei Wei

doi:10.1371/journal.pgen.1011678

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Open Access

Peer-reviewed

Research Article

Mitochondrial fission surveillance is coupled to Caenorhabditis elegans DNA and chromosome segregation integrity

Xiaomeng Yang ,

Contributed equally to this work with: Xiaomeng Yang, Ruichen Wei, Fanfan Meng

Roles Data curation, Formal analysis, Methodology, Project administration, Resources, Software

Affiliation College of Life Sciences, Capital Normal University, Beijing, China
⨯
Ruichen Wei ,

Contributed equally to this work with: Xiaomeng Yang, Ruichen Wei, Fanfan Meng

Roles Data curation, Formal analysis, Methodology, Project administration, Resources

Affiliation College of Life Sciences, Capital Normal University, Beijing, China
⨯
Fanfan Meng ,

Contributed equally to this work with: Xiaomeng Yang, Ruichen Wei, Fanfan Meng

Roles Data curation, Formal analysis, Methodology, Resources

Affiliation College of Life Sciences, Capital Normal University, Beijing, China
⨯
Dianchen Liu,

Roles Formal analysis, Methodology, Software

Affiliation College of Life Sciences, Capital Normal University, Beijing, China
⨯
Xuan Gong,

Roles Formal analysis, Methodology, Software

Affiliation College of Life Sciences, Capital Normal University, Beijing, China
⨯
Gary Ruvkun ,

Roles Funding acquisition, Investigation, Supervision, Writing – review & editing

* E-mail: ruvkun@molbio.mgh.harvard.edu (GR), weiw@cnu.edu.cn (WW)

Affiliations Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

https://orcid.org/0000-0002-7473-8484

⨯
Wei Wei

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

* E-mail: ruvkun@molbio.mgh.harvard.edu (GR), weiw@cnu.edu.cn (WW)

Affiliation College of Life Sciences, Capital Normal University, Beijing, China

https://orcid.org/0000-0002-8699-8742

⨯

Mitochondrial fission surveillance is coupled to Caenorhabditis elegans DNA and chromosome segregation integrity

Xiaomeng Yang,
Ruichen Wei,
Fanfan Meng,
Dianchen Liu,
Xuan Gong,
Gary Ruvkun,
Wei Wei

Published: April 25, 2025
https://doi.org/10.1371/journal.pgen.1011678

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Mitochondria
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RNA interference
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Muscle cells
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Embryonic pattern formation
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Caenorhabditis elegans
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Genetic screens
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