The ubiquitin ligase HUWE1 enhances WNT signaling by antagonizing destruction complex-mediated β-catenin degradation and through a mechanism independent of changes in β-catenin abundance

• Joseph K. McKenna ,

  Contributed equally to this work with: Joseph K. McKenna, Yalan Wu

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  ¶¤a Current address: Department of Molecular and Cell Biology, University of California, Berkely, California, United States of America

  Affiliation Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

  https://orcid.org/0000-0002-3921-4933

  ⨯
• Yalan Wu ,

  Contributed equally to this work with: Joseph K. McKenna, Yalan Wu

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  ¶¤b Current address: Medical Scientist Training Program, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

  Affiliation Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

  ⨯
• Praveen Sonkusre ,

  Roles Formal analysis, Investigation, Visualization

  ¶‡ PS and CKS contributed equally to this work and are listed in the order in which they started working on this project.

  Affiliation Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

  https://orcid.org/0000-0002-6404-0162

  ⨯
• Caleb K. Sinclear ,

  Roles Formal analysis, Investigation, Visualization

  ¶‡ PS and CKS contributed equally to this work and are listed in the order in which they started working on this project.

  Affiliation Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

  https://orcid.org/0000-0001-8703-856X

  ⨯
• Raj Chari,

  Roles Resources

  Affiliation Genome Modification Core, Laboratory Animal Sciences Program, Frederick National Lab for Cancer Research, Frederick, Maryland, United States of America

  https://orcid.org/0000-0002-2216-313X

  ⨯
• Andres M. Lebensohn

  Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: andres.lebensohn@nih.gov

  Affiliation Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

  https://orcid.org/0000-0002-4224-8819

  ⨯