Characterization of eclosion hormone receptor function reveals differential hormonal control of ecdysis during Drosophila development

Valeria Silva; Robert Scott; Paulina Guajardo; Haojiang Luan; Ruben Herzog; Benjamin H. White; John Ewer

doi:10.1371/journal.pgen.1011672

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Peer-reviewed

Research Article

Characterization of eclosion hormone receptor function reveals differential hormonal control of ecdysis during Drosophila development

Valeria Silva,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing

Affiliation Instituto de Neurociencias, and Centro Interdisciplinario de Neurociencia de Valparaíso, Universidad de Valparaíso, Valparaíso, Chile

https://orcid.org/0000-0003-4598-0973

⨯
Robert Scott,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – review & editing

Affiliation Laboratory of Molecular Biology, National Institute of Mental Health, NIH, Bethesda, Maryland, United States of America

https://orcid.org/0009-0000-0355-7996

⨯
Paulina Guajardo,

Roles Conceptualization, Investigation, Writing – review & editing

Affiliation Instituto de Neurociencias, and Centro Interdisciplinario de Neurociencia de Valparaíso, Universidad de Valparaíso, Valparaíso, Chile

https://orcid.org/0009-0005-7541-0973

⨯
Haojiang Luan,

Roles Investigation, Validation

Affiliation Laboratory of Molecular Biology, National Institute of Mental Health, NIH, Bethesda, Maryland, United States of America
⨯
Ruben Herzog,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation

Affiliation Université de la Sorbonne, Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, Paris, France
⨯
Benjamin H. White,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Resources, Writing – original draft, Writing – review & editing

Affiliation Laboratory of Molecular Biology, National Institute of Mental Health, NIH, Bethesda, Maryland, United States of America
⨯
John Ewer

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: john.ewer@uv.cl

Affiliation Instituto de Neurociencias, and Centro Interdisciplinario de Neurociencia de Valparaíso, Universidad de Valparaíso, Valparaíso, Chile

https://orcid.org/0000-0002-6806-3628

⨯

Characterization of eclosion hormone receptor function reveals differential hormonal control of ecdysis during Drosophila development

Valeria Silva,
Robert Scott,
Paulina Guajardo,
Haojiang Luan,
Ruben Herzog,
Benjamin H. White,
John Ewer

Published: August 20, 2025
https://doi.org/10.1371/journal.pgen.1011672

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Drosophila melanogaster
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