Local genetic covariance analysis with lipid traits identifies novel loci for early-onset Alzheimer’s Disease

• Nicholas R. Ray,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliations Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University, New York, New York, United States of America, Gertrude H. Sergievsky Center, Columbia University, New York, New York, United States of America

  https://orcid.org/0009-0009-4931-3239

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• Joseph Bradley,

  Roles Formal analysis, Resources

  Affiliation NeuroGenomics and Informatics Center, Washington University School of Medicine in St. Louis, St. Louis, Missouri, United States of America

  https://orcid.org/0000-0003-0217-4808

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• Elanur Yilmaz,

  Roles Formal analysis

  Affiliations Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University, New York, New York, United States of America, Gertrude H. Sergievsky Center, Columbia University, New York, New York, United States of America

  https://orcid.org/0000-0001-7045-5068

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• Caghan Kizil,

  Roles Formal analysis, Methodology

  Affiliations Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University, New York, New York, United States of America, Gertrude H. Sergievsky Center, Columbia University, New York, New York, United States of America

  https://orcid.org/0000-0002-8164-9762

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• Jiji T. Kurup,

  Roles Formal analysis

  Affiliations Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University, New York, New York, United States of America, Gertrude H. Sergievsky Center, Columbia University, New York, New York, United States of America

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• Eden R. Martin,

  Roles Conceptualization, Investigation

  Affiliation The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, United States of America

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• Hans-Ulrich Klein,

  Roles Conceptualization, Investigation

  Affiliations Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University, New York, New York, United States of America, Gertrude H. Sergievsky Center, Columbia University, New York, New York, United States of America

  https://orcid.org/0000-0002-6382-9428

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• Brian W. Kunkle,

  Roles Conceptualization, Investigation

  Affiliation The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, United States of America

  https://orcid.org/0000-0002-9515-5157

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• David A. Bennett,

  Roles Conceptualization, Investigation, Writing – review & editing

  Affiliation RUSH Alzheimer’s Disease Center, RUSH University, Chicago, Illinois, United States of America

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• Philip L. De Jager,

  Roles Conceptualization, Investigation

  Affiliations Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University, New York, New York, United States of America, Gertrude H. Sergievsky Center, Columbia University, New York, New York, United States of America

  https://orcid.org/0000-0002-8057-2505

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• Alzheimer’s Disease Genetics Consortium ,

  ¶Membership of Alzheimer’s Disease Genetics Consortium is provided in the Acknowledgments.

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• Gary W. Beecham,

  Roles Conceptualization, Funding acquisition, Investigation, Writing – review & editing

  Affiliation The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, United States of America

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• Carlos Cruchaga,

  Roles Conceptualization, Funding acquisition, Investigation, Writing – review & editing

  Affiliation NeuroGenomics and Informatics Center, Washington University School of Medicine in St. Louis, St. Louis, Missouri, United States of America

  https://orcid.org/0000-0002-0276-2899

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• Christiane Reitz

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: cr2101@cumc.columbia.edu

  Affiliations Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University, New York, New York, United States of America, Gertrude H. Sergievsky Center, Columbia University, New York, New York, United States of America

  https://orcid.org/0000-0001-8757-7889

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