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RatXcan: A framework for cross-species integration of genome-wide association and gene expression data
- Natasha Santhanam ,
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Sandra Sanchez-Roige ,
Contributed equally to this work with: Natasha Santhanam, Sandra Sanchez-Roige
Roles Conceptualization, Formal analysis, Methodology, Project administration, Software, Supervision, Validation, Writing – original draft, Writing – review & editing
Affiliations Department of Psychiatry, University of California San Diego, La Jolla, California, United States of America, Institute for Genomic Medicine, University of California San Diego, La Jolla, California, United States of America, Department of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
⨯ -
Sabrina Mi,
Roles Formal analysis, Visualization, Writing – review & editing
Affiliation Department of Psychiatry, University of California San Diego, La Jolla, California, United States of America
⨯ -
Yanyu Liang,
Roles Formal analysis, Writing – review & editing
Affiliation Department of Medicine, Section of Genetic Medicine, The University of Chicago, Chicago, Illinois, United States of America
⨯ -
Apurva S. Chitre,
Roles Data curation, Investigation, Writing – review & editing
Affiliation Department of Psychiatry, University of California San Diego, La Jolla, California, United States of America
⨯ -
Daniel Munro,
Roles Data curation, Investigation, Writing – review & editing
Affiliation Department of Psychiatry, University of California San Diego, La Jolla, California, United States of America
⨯ -
Denghui Chen,
Roles Data curation, Investigation, Writing – review & editing
Affiliation Department of Psychiatry, University of California San Diego, La Jolla, California, United States of America
⨯ - Jianjun Gao,
-
Angel Garcia-Martinez,
Roles Data curation, Investigation, Writing – review & editing
Affiliation University of Tennessee Health Science Center, Department of Pharmacology, Addiction Science and Toxicology, Memphis, Tennessee, United States of America
⨯ - Anthony M. George,
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Alexander F. Gileta,
Roles Data curation, Investigation, Writing – review & editing
Affiliation Department of Psychiatry, University of California San Diego, La Jolla, California, United States of America
⨯ -
Wenyan Han,
Roles Data curation, Investigation, Writing – review & editing
Affiliation University of Tennessee Health Science Center, Department of Pharmacology, Addiction Science and Toxicology, Memphis, Tennessee, United States of America
⨯ -
Katie Holl,
Roles Data curation, Investigation, Writing – review & editing
Affiliation Medical College of Wisconsin, Department of Pediatrics, Milwaukee, Wisconsin, United States of America
⨯ - Alesa Hughson,
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Christopher P. King,
Roles Data curation, Investigation, Writing – review & editing
Affiliation University at Buffalo, Department of Psychology, Buffalo, New York, United States of America
⨯ - Alexander C. Lamparelli,
- Connor D. Martin,
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Festus Nyasimi,
Roles Data curation, Formal analysis, Investigation, Writing – review & editing
Affiliation Department of Medicine, Section of Genetic Medicine, The University of Chicago, Chicago, Illinois, United States of America
⨯ -
Celine L. St. Pierre,
Roles Data curation, Investigation, Writing – review & editing
Affiliation Department of Psychiatry, University of California San Diego, La Jolla, California, United States of America
⨯ -
Sarah Sumner,
Roles Data curation, Investigation, Writing – review & editing
Affiliation Department of Medicine, Section of Genetic Medicine, The University of Chicago, Chicago, Illinois, United States of America
⨯ - Jordan Tripi,
- Tengfei Wang,
- Hao Chen,
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Shelly Flagel,
Roles Funding acquisition, Project administration, Supervision, Writing – review & editing
Affiliation University of Michigan, Department of Psychiatry, Ann Arbor, Michigan, United States of America
⨯ -
Keita Ishiwari,
Roles Supervision, Writing – review & editing
Affiliations University at Buffalo, Clinical and Research Institute on Addictions, University at Buffalo, Buffalo, New York, United States of America, University at Buffalo, Department of Pharmacology and Toxicology, Buffalo, New York, United States of America
⨯ -
Paul Meyer,
Roles Funding acquisition, Project administration, Supervision, Writing – review & editing
Affiliations University at Buffalo, Clinical and Research Institute on Addictions, University at Buffalo, Buffalo, New York, United States of America, University at Buffalo, Department of Psychology, Buffalo, New York, United States of America
⨯ -
Oksana Polesskaya,
Roles Funding acquisition, Project administration, Supervision, Writing – review & editing
Affiliation Department of Psychiatry, University of California San Diego, La Jolla, California, United States of America
⨯ -
Laura Saba,
Roles Funding acquisition, Project administration, Supervision, Writing – review & editing
Affiliation University of Colorado Anschutz Medical Campus, Department of Pharmaceutical Sciences, Aurora, Colorado, United States of America
⨯ - Leah C. Solberg Woods,
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Abraham A. Palmer ,
Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing
* E-mail: aap@ucsd.edu (AAP); haky@uchicago.edu (HKI)
Affiliations Department of Psychiatry, University of California San Diego, La Jolla, California, United States of America, Institute for Genomic Medicine, University of California San Diego, La Jolla, California, United States of America
⨯ - [ ... ],
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Hae Kyung Im
Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing
* E-mail: aap@ucsd.edu (AAP); haky@uchicago.edu (HKI)
Affiliation Department of Medicine, Section of Genetic Medicine, The University of Chicago, Chicago, Illinois, United States of America
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https://orcid.org/0000-0001-6137-5699
RatXcan: A framework for cross-species integration of genome-wide association and gene expression data
- Natasha Santhanam,
- Sandra Sanchez-Roige,
- Sabrina Mi,
- Yanyu Liang,
- Apurva S. Chitre,
- Daniel Munro,
- Denghui Chen,
- Jianjun Gao,
- Angel Garcia-Martinez,
- Anthony M. George
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- Published: March 31, 2025
- https://doi.org/10.1371/journal.pgen.1011583