Pathway polygenic risk scores (pPRS) for the analysis of gene-environment interaction

• W. James Gauderman ,

  Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Project administration, Software, Supervision, Visualization, Writing – original draft

  * E-mail: JimG@usc.edu

  Affiliation Division of Biostatistics and Health Data Science, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, California, United States of America

  https://orcid.org/0000-0002-6626-9091

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• Yubo Fu,

  Roles Formal analysis, Investigation, Methodology, Software, Visualization, Writing – review & editing

  Affiliation Division of Biostatistics and Health Data Science, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, California, United States of America

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• Bryan Queme,

  Roles Data curation, Formal analysis, Methodology, Software, Writing – original draft

  Affiliation Division of Bioinformatics, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, California, United States of America

  https://orcid.org/0000-0003-1509-9982

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• Eric Kawaguchi,

  Roles Formal analysis, Methodology, Supervision, Writing – review & editing

  Affiliation Division of Biostatistics and Health Data Science, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, California, United States of America

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• Yinqiao Wang,

  Roles Data curation, Formal analysis, Validation, Writing – review & editing

  Affiliation Division of Biostatistics and Health Data Science, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, California, United States of America

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• John Morrison,

  Roles Data curation, Software, Writing – review & editing

  Affiliation Division of Biostatistics and Health Data Science, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, California, United States of America

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• Hermann Brenner,

  Roles Data curation, Writing – review & editing

  Affiliations Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany

  https://orcid.org/0000-0002-6129-1572

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• Andrew Chan,

  Roles Data curation, Writing – review & editing

  Affiliations Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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• Stephen B. Gruber,

  Roles Data curation, Writing – review & editing

  Affiliation Center for Precision Medicine and Department of Medical Oncology, City of Hope National Medical Center, Duarte, California, United States of America

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• Temitope Keku,

  Roles Data curation, Writing – review & editing

  Affiliation University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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• Li Li,

  Roles Data curation, Writing – review & editing

  Affiliation Department of Family Medicine, UVA Comprehensive Cancer Center, UVA School of Medicine, Charlottesville, Virginia, United States of America

  https://orcid.org/0000-0003-1802-9517

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• Victor Moreno,

  Roles Writing – review & editing

  Affiliations Oncology Data Analytics Program, Catalan Institute of Oncology (ICO), L’Hospitalet de Llobregat, Barcelona, Spain, Colorectal Cancer Group, ONCOBELL Program, Institut d’Investigació Biomèdica de Bellvitge (IDIBELL), L’Hospitalet de Llobregat, Barcelona, Spain, Department of Clinical Sciences, Faculty of Medicine and Health Sciences and Universitat de Barcelona Institute of Complex Systems (UBICS), University of Barcelona (UB), L’Hospitalet de Llobregat, Barcelona, Spain, Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain

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• Andrew J. Pellatt,

  Roles Data curation, Writing – review & editing

  Affiliation Intermountain Health, Salt Lake City, Utah, United States of America

  https://orcid.org/0000-0002-0127-9790

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• Ulrike Peters,

  Roles Data curation, Funding acquisition, Resources, Writing – review & editing

  Affiliations Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America, Department of Epidemiology, School of Public Health, University of Washington, Seattle, Washington, United States of America

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• N. Jewel Samadder,

  Roles Data curation, Writing – review & editing

  Affiliation Mayo Clinic Comprehensive Cancer Center, Phoenix, Arizona, United States of America

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• Stephanie L. Schmit,

  Roles Data curation, Writing – review & editing

  Affiliations Genomic Medicine Institute, Cleveland Clinic, Cleveland, Ohio, United States of America, Population and Cancer Prevention Program, Case Comprehensive Cancer Center, Cleveland, Ohio, United States of America

  https://orcid.org/0000-0001-5931-1194

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• Cornelia M. Ulrich,

  Roles Data curation, Writing – review & editing

  Affiliations Huntsman Cancer Institute, Salt Lake City, Utah, United States of America, Department of Population Sciences, University of Utah, Salt Lake City, Utah, United States of America

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• Caroline Um,

  Roles Data curation, Writing – review & editing

  Affiliation Department of Population Science, American Cancer Society, Atlanta, GeorgiaUnited States of America

  https://orcid.org/0000-0001-5449-6230

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• Anna Wu,

  Roles Data curation, Writing – review & editing

  Affiliation Department of Population and Public Health Sciences, University of Southern California, Los Angeles, California, United States of America

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• Juan Pablo Lewinger,

  Roles Methodology, Writing – review & editing

  Affiliation Division of Biostatistics and Health Data Science, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, California, United States of America

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• David A. Drew,

  Roles Investigation, Writing – original draft

  Affiliations Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

  https://orcid.org/0000-0002-8813-0816

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•  [ ... ],
• Huaiyu Mi

  Roles Data curation, Formal analysis, Funding acquisition, Resources, Supervision, Writing – original draft

  Affiliation Division of Bioinformatics, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, California, United States of America

  https://orcid.org/0000-0001-8721-202X

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