Leveraging cancer mutation data to inform the pathogenicity classification of germline missense variants

• Bushra Haque,

  Roles Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Validation, Visualization, Writing – original draft

  Affiliations Program in Genetics and Genome Biology, SickKids Research Institute, Toronto, Ontario, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada

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• David Cheerie,

  Roles Formal analysis, Writing – review & editing

  Affiliations Program in Genetics and Genome Biology, SickKids Research Institute, Toronto, Ontario, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada

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• Amy Pan,

  Roles Formal analysis, Writing – review & editing

  Affiliations Program in Genetics and Genome Biology, SickKids Research Institute, Toronto, Ontario, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada

  https://orcid.org/0000-0003-2939-5352

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• Meredith Curtis,

  Roles Formal analysis, Writing – review & editing

  Affiliations Program in Genetics and Genome Biology, SickKids Research Institute, Toronto, Ontario, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada

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• Thomas Nalpathamkalam,

  Roles Writing – review & editing

  Affiliation The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada

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• Jimmy Nguyen,

  Roles Formal analysis, Writing – review & editing

  Affiliations Program in Genetics and Genome Biology, SickKids Research Institute, Toronto, Ontario, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada

  https://orcid.org/0000-0002-5800-7964

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• Celine Salhab,

  Roles Formal analysis, Writing – review & editing

  Affiliations Program in Genetics and Genome Biology, SickKids Research Institute, Toronto, Ontario, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada

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• Bhooma Thiruvahindrapuram,

  Roles Data curation, Writing – review & editing

  Affiliation The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada

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• Jade Zhang,

  Roles Formal analysis, Writing – review & editing

  Affiliation Human Biology Program, University of Toronto, Toronto, Ontario, Canada

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• Madeline Couse,

  Roles Formal analysis, Writing – review & editing

  Affiliation Centre for Computational Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada

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• Taila Hartley,

  Roles Data curation, Writing – review & editing

  Affiliation Children’s Hospital of Eastern Ontario Research Institute, University of Ottawa, Ottawa, Ontario, Canada

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• Michelle M. Morrow,

  Roles Data curation, Writing – review & editing

  Affiliation GeneDx, Gaithersburg, Maryland, United States of America

  https://orcid.org/0000-0001-9475-0934

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• E. Magda Price,

  Roles Data curation, Writing – review & editing

  Affiliation Children’s Hospital of Eastern Ontario Research Institute, University of Ottawa, Ottawa, Ontario, Canada

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• Susan Walker,

  Roles Writing – review & editing

  Affiliation Genomics England, London, United Kingdom

  https://orcid.org/0000-0002-5016-6426

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• David Malkin,

  Roles Supervision, Writing – review & editing

  Affiliation Division of Haematology/Oncology, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada

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• Frederick P. Roth,

  Roles Supervision, Writing – review & editing

  Affiliations Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada, Donnelly Centre for Cellular and Biomolecular Research (CCBR), University of Toronto, Toronto, Ontario, Canada, Lunenfeld-Tanenbaum Research Institute (LTRI), Sinai Health System, Toronto, Ontario, Canada, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Department of Computer Science, University of Toronto, Toronto, Ontario, Canada

  https://orcid.org/0000-0002-6628-649X

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•  [ ... ],
• Gregory Costain

  Roles Conceptualization, Funding acquisition, Supervision, Writing – original draft

  * E-mail: gregory.costain@sickkids.ca

  Affiliations Program in Genetics and Genome Biology, SickKids Research Institute, Toronto, Ontario, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada, The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada, Division of Clinical and Metabolic Genetics, The Hospital for Sick Children, and Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada

  https://orcid.org/0000-0003-0099-9945

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