Genetic gradual reduction of OGT activity unveils the essential role of O-GlcNAc in the mouse embryo

Sara Formichetti; Agnieszka Sadowska; Michela Ascolani; Julia Hansen; Kerstin Ganter; Christophe Lancrin; Neil Humphreys; Mathieu Boulard

doi:10.1371/journal.pgen.1011507

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Open Access

Peer-reviewed

Research Article

Genetic gradual reduction of OGT activity unveils the essential role of O-GlcNAc in the mouse embryo

Sara Formichetti,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations Epigenetics & Neurobiology Unit, EMBL Rome, European Molecular Biology Laboratory, Italy, Collaboration for joint PhD degree between EMBL and Heidelberg University, Germany

https://orcid.org/0000-0002-7907-2239

⨯
Agnieszka Sadowska,

Roles Investigation, Methodology, Validation

Affiliation Epigenetics & Neurobiology Unit, EMBL Rome, European Molecular Biology Laboratory, Italy
⨯
Michela Ascolani,

Roles Investigation, Methodology, Validation, Writing – original draft

Affiliation Epigenetics & Neurobiology Unit, EMBL Rome, European Molecular Biology Laboratory, Italy

https://orcid.org/0009-0000-4757-793X

⨯
Julia Hansen,

Roles Formal analysis, Investigation, Methodology

Affiliation Epigenetics & Neurobiology Unit, EMBL Rome, European Molecular Biology Laboratory, Italy

https://orcid.org/0000-0001-7828-1269

⨯
Kerstin Ganter,

Roles Resources

Affiliation Epigenetics & Neurobiology Unit, EMBL Rome, European Molecular Biology Laboratory, Italy
⨯
Christophe Lancrin,

Roles Resources, Supervision

Affiliation Epigenetics & Neurobiology Unit, EMBL Rome, European Molecular Biology Laboratory, Italy

https://orcid.org/0000-0003-0028-7374

⨯
Neil Humphreys,

Roles Methodology, Supervision, Validation, Writing – original draft

Affiliation Epigenetics & Neurobiology Unit, EMBL Rome, European Molecular Biology Laboratory, Italy
⨯
Mathieu Boulard

Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

* E-mail: matthieu.boulard@embl.it

Affiliation Epigenetics & Neurobiology Unit, EMBL Rome, European Molecular Biology Laboratory, Italy

https://orcid.org/0000-0001-5135-8529

⨯

Genetic gradual reduction of OGT activity unveils the essential role of O-GlcNAc in the mouse embryo

Sara Formichetti,
Agnieszka Sadowska,
Michela Ascolani,
Julia Hansen,
Kerstin Ganter,
Christophe Lancrin,
Neil Humphreys,
Mathieu Boulard

Published: January 9, 2025
https://doi.org/10.1371/journal.pgen.1011507
See the preprint

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Blastocysts
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Embryos
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Auxins
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Retrotransposons
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Gene expression
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Gene ontologies
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Heterozygosity
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Transcriptome analysis
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