Single-cell analysis of gene regulatory networks in the mammary glands of P4HA1-knockout mice

Akshat Gupta; Lilin Huang; Jinpeng Liu; Ke Chen; Ren Xu; Wei Wu

doi:10.1371/journal.pgen.1011505

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Open Access

Peer-reviewed

Research Article

Single-cell analysis of gene regulatory networks in the mammary glands of P4HA1-knockout mice

Akshat Gupta,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Ray and Stephanie Lane Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States of America
⨯
Lilin Huang,

Roles Formal analysis, Investigation, Methodology, Software

Affiliation Ray and Stephanie Lane Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States of America

https://orcid.org/0009-0004-5579-1724

⨯
Jinpeng Liu,

Roles Data curation, Methodology, Resources

Affiliations Markey Cancer Center, University of Kentucky, Lexington, Kentucky, United States of America, Department of Pharmacology and Nutritional Science, University of Kentucky, Lexington, Kentucky, United States of America
⨯
Ke Chen,

Roles Formal analysis

Affiliation Ray and Stephanie Lane Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States of America
⨯
Ren Xu ,

Roles Conceptualization, Data curation, Funding acquisition, Methodology, Resources, Supervision, Validation, Writing – review & editing

* E-mail: rxu222@uky.edu (RX), weiwu2@cs.cmu.edu (WW)

Affiliations Markey Cancer Center, University of Kentucky, Lexington, Kentucky, United States of America, Department of Pharmacology and Nutritional Science, University of Kentucky, Lexington, Kentucky, United States of America
⨯
Wei Wu

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: rxu222@uky.edu (RX), weiwu2@cs.cmu.edu (WW)

Affiliation Ray and Stephanie Lane Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States of America

https://orcid.org/0000-0002-1411-9120

⨯

Single-cell analysis of gene regulatory networks in the mammary glands of P4HA1-knockout mice

Akshat Gupta,
Lilin Huang,
Jinpeng Liu,
Ke Chen,
Ren Xu,
Wei Wu

Published: July 22, 2025
https://doi.org/10.1371/journal.pgen.1011505

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Regulons
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Epithelial cells
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Macrophages
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Breast cancer
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Genetically modified animals
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Gene expression
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Mammary glands
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Inflammation
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