Integrin adhesome axis inhibits the RPM-1 ubiquitin ligase signaling hub to regulate growth cone and axon development

• Jonathan Amezquita ,

  Contributed equally to this work with: Jonathan Amezquita, Muriel Desbois

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliations Center for Integrative Brain Research, Seattle Children’s Research Institute, Seattle, Washington, United States of America, Molecular and Cellular Biology Graduate Program, University of Washington, Seattle, Washington, United States of America

  ⨯
• Muriel Desbois ,

  Contributed equally to this work with: Jonathan Amezquita, Muriel Desbois

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation School of Life Sciences, Keele University, Keele, Staffordshire, United Kingdom

  https://orcid.org/0000-0002-8070-2525

  ⨯
• Karla J. Opperman,

  Roles Data curation, Investigation, Methodology, Writing – review & editing

  Affiliation Center for Integrative Brain Research, Seattle Children’s Research Institute, Seattle, Washington, United States of America

  https://orcid.org/0000-0001-9545-8361

  ⨯
• Joseph S. Pak,

  Roles Data curation, Methodology, Writing – review & editing

  Affiliation Center for Integrative Brain Research, Seattle Children’s Research Institute, Seattle, Washington, United States of America

  ⨯
• Elyse L. Christensen,

  Roles Data curation, Formal analysis, Investigation

  Affiliation Molecular and Cellular Biology Graduate Program, University of Washington, Seattle, Washington, United States of America

  https://orcid.org/0000-0003-2117-1602

  ⨯
• Nikki T. Nguyen,

  Roles Methodology

  Affiliation Center for Integrative Brain Research, Seattle Children’s Research Institute, Seattle, Washington, United States of America

  https://orcid.org/0009-0005-5159-2530

  ⨯
• Karen Diaz-Garcia,

  Roles Data curation, Investigation

  Affiliation Center for Integrative Brain Research, Seattle Children’s Research Institute, Seattle, Washington, United States of America

  ⨯
• Melissa A. Borgen,

  Roles Conceptualization, Methodology, Writing – review & editing

  Affiliation Florida Institute of Technology, Department of Biomedical Engineering and Sciences, Melbourne, United States of America

  https://orcid.org/0000-0003-2600-9946

  ⨯
• Brock Grill

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: brock.grill@seattlechildrens.org

  Affiliations Center for Integrative Brain Research, Seattle Children’s Research Institute, Seattle, Washington, United States of America, Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington, United States of America, Department of Pharmacology, University of Washington School of Medicine, Seattle, Washington, United States of America

  https://orcid.org/0000-0002-0379-3267

  ⨯