Neuronal fatty acid-binding protein enhances autophagy and suppresses amyloid-β pathology in a Drosophila model of Alzheimer’s disease

Seokhui Jang; Byoungyun Choi; Chaejin Lim; Minkyoung Kim; Ji-Eun Lee; Hyungi Lee; Eunji Baek; Kyoung Sang Cho

doi:10.1371/journal.pgen.1011475

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Open Access

Peer-reviewed

Research Article

Neuronal fatty acid-binding protein enhances autophagy and suppresses amyloid-β pathology in a Drosophila model of Alzheimer’s disease

Seokhui Jang ,

Contributed equally to this work with: Seokhui Jang, Byoungyun Choi

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation, Visualization, Writing – review & editing

Affiliation Department of Biological Sciences, Konkuk University, Seoul, Republic of Korea
⨯
Byoungyun Choi ,

Contributed equally to this work with: Seokhui Jang, Byoungyun Choi

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Biological Sciences, Konkuk University, Seoul, Republic of Korea
⨯
Chaejin Lim,

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing

Affiliation Department of Biological Sciences, Konkuk University, Seoul, Republic of Korea
⨯
Minkyoung Kim,

Roles Formal analysis, Investigation, Writing – review & editing

Affiliation Department of Biological Sciences, Konkuk University, Seoul, Republic of Korea
⨯
Ji-Eun Lee,

Roles Formal analysis, Investigation, Writing – review & editing

Affiliation Department of Biological Sciences, Konkuk University, Seoul, Republic of Korea
⨯
Hyungi Lee,

Roles Formal analysis, Investigation, Writing – review & editing

Affiliation Department of Biological Sciences, Konkuk University, Seoul, Republic of Korea
⨯
Eunji Baek,

Roles Formal analysis, Investigation, Writing – review & editing

Affiliation Department of Biological Sciences, Konkuk University, Seoul, Republic of Korea
⨯
Kyoung Sang Cho

Roles Conceptualization, Data curation, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: kscho@konkuk.ac.kr

Affiliations Department of Biological Sciences, Konkuk University, Seoul, Republic of Korea, Korea Hemp Institute, Konkuk University, Seoul, Republic of Korea

https://orcid.org/0000-0002-3277-8269

⨯

Neuronal fatty acid-binding protein enhances autophagy and suppresses amyloid-β pathology in a Drosophila model of Alzheimer’s disease

Seokhui Jang,
Byoungyun Choi,
Chaejin Lim,
Minkyoung Kim,
Ji-Eun Lee,
Hyungi Lee,
Eunji Baek,
Kyoung Sang Cho

Published: November 19, 2024
https://doi.org/10.1371/journal.pgen.1011475

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Autophagic cell death
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Drosophila melanogaster
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Alzheimer's disease
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Neurons
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Apoptosis
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RNA interference
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Gene expression
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