A machine learning enhanced EMS mutagenesis probability map for efficient identification of causal mutations in Caenorhabditis elegans

Zhengyang Guo; Shimin Wang; Yang Wang; Zi Wang; Guangshuo Ou

doi:10.1371/journal.pgen.1011377

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Open Access

Peer-reviewed

Research Article

A machine learning enhanced EMS mutagenesis probability map for efficient identification of causal mutations in Caenorhabditis elegans

Zhengyang Guo,

Roles Conceptualization, Data curation, Formal analysis, Methodology, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Tsinghua-Peking Center for Life Sciences, Beijing Frontier Research Center for Biological Structure, McGovern Institute for Brain Research, State Key Laboratory of Membrane Biology, School of Life Sciences and MOE Key Laboratory for Protein Science, Tsinghua University, Beijing, China

https://orcid.org/0009-0001-2746-613X

⨯
Shimin Wang,

Roles Investigation

Affiliation Tsinghua-Peking Center for Life Sciences, Beijing Frontier Research Center for Biological Structure, McGovern Institute for Brain Research, State Key Laboratory of Membrane Biology, School of Life Sciences and MOE Key Laboratory for Protein Science, Tsinghua University, Beijing, China
⨯
Yang Wang,

Roles Formal analysis, Visualization

Affiliation Tsinghua-Peking Center for Life Sciences, Beijing Frontier Research Center for Biological Structure, McGovern Institute for Brain Research, State Key Laboratory of Membrane Biology, School of Life Sciences and MOE Key Laboratory for Protein Science, Tsinghua University, Beijing, China

https://orcid.org/0009-0004-6696-5179

⨯
Zi Wang,

Roles Investigation

Affiliation Tsinghua-Peking Center for Life Sciences, Beijing Frontier Research Center for Biological Structure, McGovern Institute for Brain Research, State Key Laboratory of Membrane Biology, School of Life Sciences and MOE Key Laboratory for Protein Science, Tsinghua University, Beijing, China
⨯
Guangshuo Ou

Roles Conceptualization, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

* E-mail: guangshuoou@tsinghua.edu.cn

Affiliation Tsinghua-Peking Center for Life Sciences, Beijing Frontier Research Center for Biological Structure, McGovern Institute for Brain Research, State Key Laboratory of Membrane Biology, School of Life Sciences and MOE Key Laboratory for Protein Science, Tsinghua University, Beijing, China

https://orcid.org/0000-0003-1512-7824

⨯

A machine learning enhanced EMS mutagenesis probability map for efficient identification of causal mutations in Caenorhabditis elegans

Zhengyang Guo,
Shimin Wang,
Yang Wang,
Zi Wang,
Guangshuo Ou

Published: August 26, 2024
https://doi.org/10.1371/journal.pgen.1011377

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Mutagenesis
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Genetic screens
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DNA-binding proteins
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Gene mapping
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Caenorhabditis elegans
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Suppressor genes
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Genetic suppression
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Invertebrate genomics
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