Floxuridine supports UPS independent of germline signaling and proteostasis regulators via involvement of detoxification in C. elegans

Abhishek Anil Dubey; Anwesha Sarkar; Karolina Milcz; Natalia A. Szulc; Pankaj Thapa; Małgorzata Piechota; Remigiusz A. Serwa; Wojciech Pokrzywa

doi:10.1371/journal.pgen.1011371

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Open Access

Peer-reviewed

Research Article

Floxuridine supports UPS independent of germline signaling and proteostasis regulators via involvement of detoxification in C. elegans

Abhishek Anil Dubey,

Roles Conceptualization, Formal analysis, Investigation, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Laboratory of Protein Metabolism, International Institute of Molecular and Cell Biology in Warsaw, Warsaw, Poland

https://orcid.org/0000-0003-2285-7526

⨯
Anwesha Sarkar,

Roles Formal analysis, Investigation, Validation, Visualization

Affiliation Laboratory of Protein Metabolism, International Institute of Molecular and Cell Biology in Warsaw, Warsaw, Poland

https://orcid.org/0000-0002-2150-9653

⨯
Karolina Milcz,

Roles Formal analysis, Investigation, Visualization

Affiliation Laboratory of Protein Metabolism, International Institute of Molecular and Cell Biology in Warsaw, Warsaw, Poland

https://orcid.org/0009-0000-7650-8407

⨯
Natalia A. Szulc,

Roles Data curation, Formal analysis, Visualization, Writing – review & editing

Affiliation Laboratory of Protein Metabolism, International Institute of Molecular and Cell Biology in Warsaw, Warsaw, Poland

https://orcid.org/0000-0002-2991-3634

⨯
Pankaj Thapa,

Roles Investigation

Affiliation Laboratory of Protein Metabolism, International Institute of Molecular and Cell Biology in Warsaw, Warsaw, Poland
⨯
Małgorzata Piechota,

Roles Investigation

Affiliation Laboratory of Protein Metabolism, International Institute of Molecular and Cell Biology in Warsaw, Warsaw, Poland

https://orcid.org/0000-0001-7511-8626

⨯
Remigiusz A. Serwa,

Roles Investigation

Affiliation IMol Polish Academy of Sciences, Warsaw, Poland

https://orcid.org/0000-0002-4684-3754

⨯
Wojciech Pokrzywa

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

* E-mail: wpokrzywa@iimcb.gov.pl

Affiliation Laboratory of Protein Metabolism, International Institute of Molecular and Cell Biology in Warsaw, Warsaw, Poland

https://orcid.org/0000-0002-5110-4462

⨯

Floxuridine supports UPS independent of germline signaling and proteostasis regulators via involvement of detoxification in C. elegans

Abhishek Anil Dubey,
Anwesha Sarkar,
Karolina Milcz,
Natalia A. Szulc,
Pankaj Thapa,
Małgorzata Piechota,
Remigiusz A. Serwa,
Wojciech Pokrzywa

Published: July 31, 2024
https://doi.org/10.1371/journal.pgen.1011371

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Proteasomes
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RNA interference
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Caenorhabditis elegans
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Young adults
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Detoxification
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Protein synthesis
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