A comprehensive framework for trans-ancestry pathway analysis using GWAS summary data from diverse populations

• Sheng Fu,

  Roles Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations School of Statistics and Data Science, Nankai University, Tianjin, China, Key Laboratory of Pure Mathematics and Combinatorics, Nankai University, Tianjin, China

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• William Wheeler,

  Roles Methodology, Software, Writing – review & editing

  Affiliation Information Management Services, Inc, Bethesda, Maryland, United States of America

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• Xiaoyu Wang,

  Roles Data curation, Formal analysis, Software, Validation, Visualization, Writing – review & editing

  Affiliations Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America, Cancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc, Rockville, Maryland, United States of America

  https://orcid.org/0009-0005-5143-6909

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• Xing Hua,

  Roles Data curation, Formal analysis, Software, Validation, Writing – review & editing

  Affiliations Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America, Cancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc, Rockville, Maryland, United States of America

  https://orcid.org/0000-0002-8346-5887

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• Devika Godbole,

  Roles Formal analysis, Software, Visualization, Writing – review & editing

  Affiliations Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America, Cancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc, Rockville, Maryland, United States of America

  https://orcid.org/0000-0003-4897-0367

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• Jubao Duan,

  Roles Data curation, Methodology, Resources, Writing – review & editing

  Affiliations Center for Psychiatric Genetics, NorthShore University HealthSystem, Evanston, Illinois, United States of America, Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, Illinois, United States of America

  https://orcid.org/0000-0002-7215-3220

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• Bin Zhu,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America

  https://orcid.org/0000-0003-0172-5516

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• Lu Deng,

  Roles Methodology, Writing – review & editing

  Affiliation School of Statistics and Data Science, Nankai University, Tianjin, China

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• Fei Qin,

  Roles Methodology, Writing – review & editing

  Affiliation Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America

  https://orcid.org/0000-0003-3678-2879

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• Haoyu Zhang,

  Roles Investigation, Methodology, Resources, Writing – review & editing

  Affiliation Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America

  https://orcid.org/0000-0001-6423-0444

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• Jianxin Shi,

  Roles Investigation, Methodology, Resources, Writing – review & editing

  Affiliation Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America

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• Kai Yu

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: yuka@mail.nih.gov

  Affiliation Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America

  https://orcid.org/0000-0002-5337-137X

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