Trajectory-centric framework TrajAtlas reveals multi-scale differentiation heterogeneity among cells, genes, and gene modules in osteogenesis

• Litian Han ,

  Contributed equally to this work with: Litian Han, Yaoting Ji

  Roles Data curation, Formal analysis, Software, Validation, Writing – original draft

  Affiliation State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, Hubei Province, China

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• Yaoting Ji ,

  Contributed equally to this work with: Litian Han, Yaoting Ji

  Roles Conceptualization, Writing – review & editing

  Affiliation State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, Hubei Province, China

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• Yiqian Yu,

  Roles Validation

  Affiliation State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, Hubei Province, China

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• Yueqi Ni,

  Roles Validation

  Affiliation State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, Hubei Province, China

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• Hao Zeng,

  Roles Data curation, Software

  Affiliation State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, Hubei Province, China

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• Xiaoxin Zhang,

  Roles Data curation

  Affiliation State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, Hubei Province, China

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• Huan Liu ,

  Roles Conceptualization, Resources, Writing – review & editing

  * E-mail: liu.huan@whu.edu.cn (HL); zyf@whu.edu.cn (YZ)

  Affiliations State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, Hubei Province, China, Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan, Hubei Province, China, TaiKang Center for Life and Medical Sciences, Wuhan University, Wuhan, Hubei Province, China

  https://orcid.org/0000-0002-9947-6687

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• Yufeng Zhang

  Roles Conceptualization

  * E-mail: liu.huan@whu.edu.cn (HL); zyf@whu.edu.cn (YZ)

  Affiliations State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, Hubei Province, China, Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan, Hubei Province, China, TaiKang Center for Life and Medical Sciences, Wuhan University, Wuhan, Hubei Province, China

  https://orcid.org/0000-0001-8702-5291

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