History of tuberculosis disease is associated with genetic regulatory variation in Peruvians

• Victor E. Nieto-Caballero ,

  Roles Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  ¶☯ Victor Nieto-Caballeri and Josephine Reijneveld contributed equally to this work.

  Affiliations Division of Immunology, Department of Pediatrics, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Undergraduate Program in Genomic Sciences, Center for Genomic Sciences, Universidad Nacional Autónoma de México (UNAM), Morelos, Mexico, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

  https://orcid.org/0000-0002-5217-0330

  ⨯
• Josephine F. Reijneveld ,

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  ¶☯ Victor Nieto-Caballeri and Josephine Reijneveld contributed equally to this work.

  Affiliation Zuckerberg San Francisco General Hospital, Division of Experimental Medicine, University of California San Francisco, San Francisco, California, United States of America

  https://orcid.org/0000-0001-8695-964X

  ⨯
• Angel Ruvalcaba,

  Roles Formal analysis, Investigation, Methodology, Validation

  Affiliation Zuckerberg San Francisco General Hospital, Division of Experimental Medicine, University of California San Francisco, San Francisco, California, United States of America

  https://orcid.org/0009-0002-1043-8068

  ⨯
• Gabriel Innocenzi,

  Roles Methodology, Validation

  Affiliation Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America

  ⨯
• Nalin Abeydeera,

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – review & editing

  Affiliation Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America

  ⨯
• Samira Asgari,

  Roles Data curation, Formal analysis, Investigation, Software, Writing – review & editing

  Affiliations Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Division of Rheumatology, Inflammation and Immunity, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, United States of America, Center for Data Sciences, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Institute for Genomic Health, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America

  https://orcid.org/0000-0002-2347-8985

  ⨯
• Kattya Lopez,

  Roles Investigation, Methodology, Project administration

  Affiliations Division of Rheumatology, Inflammation and Immunity, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Socios En Salud Sucursal Peru, Lima, Peru

  ⨯
• Sarah K. Iwany,

  Roles Data curation, Formal analysis, Investigation, Methodology

  Affiliation Division of Rheumatology, Inflammation and Immunity, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

  ⨯
• Yang Luo,

  Roles Data curation, Formal analysis, Investigation, Software, Writing – review & editing

  Affiliations Division of Immunology, Department of Pediatrics, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Division of Rheumatology, Inflammation and Immunity, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, United States of America, Center for Data Sciences, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom

  ⨯
• Aparna Nathan,

  Roles Data curation, Formal analysis, Investigation, Software, Writing – review & editing

  Affiliations Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Division of Rheumatology, Inflammation and Immunity, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, United States of America, Center for Data Sciences, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

  https://orcid.org/0000-0002-5975-2851

  ⨯
• Daniela Fernandez-Salinas,

  Roles Data curation, Formal analysis, Investigation, Software, Visualization

  Affiliation Division of Immunology, Department of Pediatrics, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

  ⨯
• Marcos Chiñas,

  Roles Data curation, Formal analysis, Investigation, Software, Visualization

  Affiliations Division of Immunology, Department of Pediatrics, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

  https://orcid.org/0000-0003-0275-1302

  ⨯
• Chuan-Chin Huang,

  Roles Data curation, Resources, Software

  Affiliation Department of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

  ⨯
• Zibiao Zhang,

  Roles Data curation, Resources, Software

  Affiliation Department of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

  ⨯
• Segundo R. León,

  Roles Investigation, Methodology, Resources

  Affiliations Socios En Salud Sucursal Peru, Lima, Peru, Medical Technology School and Global Health Research Institute, San Juan Bautista Private University, Lima, Perú

  https://orcid.org/0000-0002-5630-5714

  ⨯
• Roger I. Calderon,

  Roles Investigation, Methodology, Resources

  Affiliation Socios En Salud Sucursal Peru, Lima, Peru

  ⨯
• Leonid Lecca,

  Roles Conceptualization, Data curation, Investigation, Methodology, Resources

  Affiliation Socios En Salud Sucursal Peru, Lima, Peru

  ⨯
• Jonathan M. Budzik,

  Roles Investigation, Methodology, Resources, Validation, Writing – review & editing

  Affiliation Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America

  https://orcid.org/0000-0001-8025-7911

  ⨯
• Megan Murray,

  Roles Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Resources, Supervision, Writing – review & editing

  Affiliation Department of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

  https://orcid.org/0000-0003-0443-1986

  ⨯
• Ildiko Van Rhijn,

  Roles Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – review & editing

  Affiliations Division of Rheumatology, Inflammation and Immunity, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands

  ⨯
• Soumya Raychaudhuri,

  Roles Conceptualization, Data curation, Funding acquisition, Methodology, Project administration, Supervision, Writing – review & editing

  Affiliations Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Division of Rheumatology, Inflammation and Immunity, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, United States of America, Center for Data Sciences, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

  ⨯
• D. Branch Moody,

  Roles Conceptualization, Data curation, Funding acquisition, Investigation, Project administration, Resources, Supervision, Writing – review & editing

  Affiliation Division of Rheumatology, Inflammation and Immunity, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

  ⨯
• Sara Suliman ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: sara.suliman@ucsf.edu (SS); mgutierr@broadinstitute.org (MGA)

  ¶‡ Sara Suliman and Maria Gutierrez-Arcelus contributed equally to this work.

  Affiliations Division of Rheumatology, Inflammation and Immunity, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Zuckerberg San Francisco General Hospital, Division of Experimental Medicine, University of California San Francisco, San Francisco, California, United States of America, Gladstone-UCSF Institute of Genomic Immunology, University of California San Francisco, San Francisco, California, United States of America, Chan Zuckerberg Initiative Biohub, San Francisco, California, United States of America

  https://orcid.org/0000-0002-5154-576X

  ⨯
•  [ ... ],
• Maria Gutierrez-Arcelus

  Roles Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: sara.suliman@ucsf.edu (SS); mgutierr@broadinstitute.org (MGA)

  ¶‡ Sara Suliman and Maria Gutierrez-Arcelus contributed equally to this work.

  Affiliations Division of Immunology, Department of Pediatrics, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Division of Rheumatology, Inflammation and Immunity, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, United States of America, Center for Data Sciences, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

  https://orcid.org/0000-0001-7898-7691

  ⨯
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