CRISPR screen for protein inclusion formation uncovers a role for SRRD in the regulation of intermediate filament dynamics and aggresome assembly

• Katelyn M. Sweeney,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Validation, Visualization, Writing – original draft

  Affiliations Center for Cellular and Molecular Therapeutics, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America, Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

  https://orcid.org/0000-0001-6659-8859

  ⨯
• Sapanna Chantarawong,

  Roles Investigation, Methodology

  Affiliations Center for Cellular and Molecular Therapeutics, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America, Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

  https://orcid.org/0009-0004-3169-2625

  ⨯
• Edward M. Barbieri,

  Roles Investigation

  Affiliation Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

  https://orcid.org/0000-0001-9059-6773

  ⨯
• Greg Cajka,

  Roles Investigation

  Affiliations Center for Cellular and Molecular Therapeutics, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America, Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

  https://orcid.org/0000-0002-7537-8310

  ⨯
• Matthew Liu,

  Roles Investigation

  Affiliations Center for Cellular and Molecular Therapeutics, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America, Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

  https://orcid.org/0000-0002-5004-9182

  ⨯
• Lynn Spruce,

  Roles Supervision

  Affiliation Proteomics Core Facility, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

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• Hossein Fazelinia,

  Roles Investigation

  Affiliations Proteomics Core Facility, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America, Department of Biomedical and Health Informatics, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

  ⨯
• Bede Portz,

  Roles Investigation

  Affiliation Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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• Katie Copley,

  Roles Investigation

  Affiliation Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

  ⨯
• Tomer Lapidot,

  Roles Investigation

  Affiliations Center for Cellular and Molecular Therapeutics, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America, Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

  ⨯
• Lauren Duhamel,

  Roles Investigation

  Affiliations Center for Cellular and Molecular Therapeutics, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America, Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

  ⨯
• Phoebe Greenwald,

  Roles Investigation

  Affiliations Center for Cellular and Molecular Therapeutics, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America, Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

  https://orcid.org/0009-0006-0567-9755

  ⨯
• Naseeb Saida,

  Roles Investigation

  Affiliation Department of Biochemistry, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel

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• Reut Shalgi,

  Roles Supervision

  Affiliation Department of Biochemistry, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel

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• James Shorter,

  Roles Supervision

  Affiliation Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

  https://orcid.org/0000-0001-5269-8533

  ⨯
•  [ ... ],
• Ophir Shalem

  Roles Conceptualization, Data curation, Formal analysis, Project administration, Supervision

  * E-mail: shalemo@upenn.edu

  Affiliations Center for Cellular and Molecular Therapeutics, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America, Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

  https://orcid.org/0000-0002-2267-0801

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