Precision pharmacological reversal of strain-specific diet-induced metabolic syndrome in mice informed by epigenetic and transcriptional regulation

• Phillip Wulfridge ,

  Contributed equally to this work with: Phillip Wulfridge, Adam Davidovich, Anna C. Salvador

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Software, Visualization, Writing – original draft, Writing – review & editing

  Current address: The Wistar Institute, Philadelphia, Pennsylvania, United States of America

  Affiliation Center for Epigenetics, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America

  https://orcid.org/0000-0002-7195-6814

  ⨯
• Adam Davidovich ,

  Contributed equally to this work with: Phillip Wulfridge, Adam Davidovich, Anna C. Salvador

  Roles Data curation, Formal analysis, Investigation, Methodology, Project administration, Software, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Center for Epigenetics, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America, Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, United States of America

  https://orcid.org/0000-0002-2543-1873

  ⨯
• Anna C. Salvador ,

  Contributed equally to this work with: Phillip Wulfridge, Adam Davidovich, Anna C. Salvador

  Roles Data curation, Formal analysis, Investigation, Methodology, Project administration, Writing – original draft, Writing – review & editing

  Affiliations Department of Cell Biology and Genetics, Texas A&M Health Science Center, College Station, Texas, United States of America, Department of Nutrition, Texas A&M University, College Station, Texas, United States of America

  https://orcid.org/0000-0003-4218-631X

  ⨯
• Gabrielle C. Manno,

  Roles Data curation, Investigation

  Affiliation Department of Cell Biology and Genetics, Texas A&M Health Science Center, College Station, Texas, United States of America

  ⨯
• Rakel Tryggvadottir,

  Roles Data curation, Investigation, Writing – original draft

  Affiliation Center for Epigenetics, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America

  https://orcid.org/0000-0003-0225-9086

  ⨯
• Adrian Idrizi,

  Roles Data curation, Investigation, Writing – original draft

  Affiliation Center for Epigenetics, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America

  https://orcid.org/0009-0005-3225-9249

  ⨯
• M. Nazmul Huda,

  Roles Formal analysis, Investigation

  Affiliations Department of Nutrition, University of California, Davis, California, United States of America, Obesity and Metabolism Research Unit, USDA, ARS, Western Human Nutrition Research Center, Davis, California, United States of America

  https://orcid.org/0000-0003-2775-4470

  ⨯
• Brian J. Bennett,

  Roles Formal analysis, Investigation

  Affiliations Department of Nutrition, University of California, Davis, California, United States of America, Obesity and Metabolism Research Unit, USDA, ARS, Western Human Nutrition Research Center, Davis, California, United States of America

  https://orcid.org/0000-0002-0766-3195

  ⨯
• L. Garry Adams,

  Roles Formal analysis, Investigation

  Affiliation Department of Veterinary Pathobiology, Texas A&M University, College Station, Texas, United States of America

  https://orcid.org/0000-0002-7246-1602

  ⨯
• Kasper D. Hansen ,

  Roles Conceptualization, Formal analysis, Methodology, Project administration, Supervision, Validation, Writing – review & editing

  * E-mail: khansen@jhsph.edu (KDH); dwthreadgill@tamu.edu (DWT); afeinberg@jhu.edu (APF)

  Affiliations Center for Epigenetics, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America, Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, United States of America, Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America, Department of Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America

  https://orcid.org/0000-0003-0086-0687

  ⨯
• David W. Threadgill ,

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: khansen@jhsph.edu (KDH); dwthreadgill@tamu.edu (DWT); afeinberg@jhu.edu (APF)

  Affiliations Department of Cell Biology and Genetics, Texas A&M Health Science Center, College Station, Texas, United States of America, Department of Nutrition, Texas A&M University, College Station, Texas, United States of America, Department of Biochemistry & Biophysics, Texas A&M University, College Station, Texas, United States of America

  https://orcid.org/0000-0003-3538-1635

  ⨯
• Andrew P. Feinberg

  Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: khansen@jhsph.edu (KDH); dwthreadgill@tamu.edu (DWT); afeinberg@jhu.edu (APF)

  Affiliations Center for Epigenetics, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America, Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, United States of America, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America, Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America

  https://orcid.org/0000-0002-8364-1991

  ⨯