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Open Access
Peer-reviewed
Research Article
CAG repeat expansion in the Huntington’s disease gene shapes linear and circular RNAs biogenesis
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Dilara Ayyildiz ,
Contributed equally to this work with: Dilara Ayyildiz, Guendalina Bergonzoni, Alan Monziani, Takshashila Tripathi
Roles Conceptualization, Data curation, Formal analysis, Methodology, Software, Visualization, Writing – original draft
Affiliations Bioinformatic facility, Department of Cellular, Computational and Integrative Biology, CIBIO, University of Trento, Trento, Italy, Biomedical Sciences and Biotechnology, University of Udine, Udine, Italy
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Guendalina Bergonzoni ,
Contributed equally to this work with: Dilara Ayyildiz, Guendalina Bergonzoni, Alan Monziani, Takshashila Tripathi
Roles Formal analysis, Methodology, Validation, Visualization, Writing – review & editing
Affiliation NeuroEpigenetics laboratory, Department of Cellular, Computational and Integrative Biology, CIBIO, University of Trento, Trento, Italy
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Alan Monziani ,
Contributed equally to this work with: Dilara Ayyildiz, Guendalina Bergonzoni, Alan Monziani, Takshashila Tripathi
Roles Data curation, Methodology, Validation, Writing – original draft
Affiliation NeuroEpigenetics laboratory, Department of Cellular, Computational and Integrative Biology, CIBIO, University of Trento, Trento, Italy
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Takshashila Tripathi ,
Contributed equally to this work with: Dilara Ayyildiz, Guendalina Bergonzoni, Alan Monziani, Takshashila Tripathi
Roles Methodology, Project administration, Validation, Writing – review & editing
Affiliation NeuroEpigenetics laboratory, Department of Cellular, Computational and Integrative Biology, CIBIO, University of Trento, Trento, Italy
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Jessica Döring,
Roles Methodology, Validation, Writing – review & editing
Affiliation NeuroEpigenetics laboratory, Department of Cellular, Computational and Integrative Biology, CIBIO, University of Trento, Trento, Italy
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Emanuela Kerschbamer,
Roles Data curation, Software
Affiliation NeuroEpigenetics laboratory, Department of Cellular, Computational and Integrative Biology, CIBIO, University of Trento, Trento, Italy
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Francesca Di Leva,
Roles Methodology, Resources
Affiliation NeuroEpigenetics laboratory, Department of Cellular, Computational and Integrative Biology, CIBIO, University of Trento, Trento, Italy
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Elia Pennati,
Roles Validation
Affiliation NeuroEpigenetics laboratory, Department of Cellular, Computational and Integrative Biology, CIBIO, University of Trento, Trento, Italy
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Luisa Donini,
Roles Validation
Affiliation NeuroEpigenetics laboratory, Department of Cellular, Computational and Integrative Biology, CIBIO, University of Trento, Trento, Italy
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Marina Kovalenko,
Roles Resources
Affiliation Molecular Neurogenetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America
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Jacopo Zasso,
Roles Methodology, Resources
Affiliation Laboratory of Stem Cell Biology, Department of Cellular, Computational and Integrative Biology, CIBIO, University of Trento, Trento, Italy
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Luciano Conti,
Roles Methodology, Resources, Supervision, Writing – review & editing
Affiliation Laboratory of Stem Cell Biology, Department of Cellular, Computational and Integrative Biology, CIBIO, University of Trento, Trento, Italy
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Vanessa C. Wheeler,
Roles Conceptualization, Funding acquisition, Resources, Supervision, Writing – original draft, Writing – review & editing
Affiliations Molecular Neurogenetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Neurology Harvard Medical School, Boston, Massachusetts, United States of America
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Christoph Dieterich,
Roles Data curation, Methodology, Resources, Software, Supervision, Writing – review & editing
Affiliation Section of Bioinformatics and Systems Cardiology, University Hospital Heidelberg, Heidelberg, Germany
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Silvano Piazza,
Roles Data curation, Software, Supervision, Writing – review & editing
Affiliation Bioinformatic facility, Department of Cellular, Computational and Integrative Biology, CIBIO, University of Trento, Trento, Italy
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Erik Dassi ,
Roles Conceptualization, Data curation, Formal analysis, Methodology, Software, Supervision, Writing – original draft, Writing – review & editing
* E-mail: erik.dassi@unitn.it (ED); marta.biagioli@unitn.it (MB)
Affiliation Laboratory of RNA Regulatory Networks, Department of Cellular, Computational and Integrative Biology, CIBIO, University of Trento, Trento, Italy
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Marta Biagioli
Roles Conceptualization, Funding acquisition, Project administration, Supervision, Validation, Writing – original draft, Writing – review & editing
* E-mail: erik.dassi@unitn.it (ED); marta.biagioli@unitn.it (MB)
Affiliation NeuroEpigenetics laboratory, Department of Cellular, Computational and Integrative Biology, CIBIO, University of Trento, Trento, Italy
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CAG repeat expansion in the Huntington’s disease gene shapes linear and circular RNAs biogenesis
- Dilara Ayyildiz,
- Guendalina Bergonzoni,
- Alan Monziani,
- Takshashila Tripathi,
- Jessica Döring,
- Emanuela Kerschbamer,
- Francesca Di Leva,
- Elia Pennati,
- Luisa Donini,
- Marina Kovalenko
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- Published: October 13, 2023
- https://doi.org/10.1371/journal.pgen.1010988