Adenylosuccinate lyase deficiency affects neurobehavior via perturbations to tyramine signaling in Caenorhabditis elegans

Corinna A. Moro; Sabrina A. Sony; Latisha P. Franklin; Shirley Dong; Mia M. Peifer; Kathryn E. Wittig; Wendy Hanna-Rose

doi:10.1371/journal.pgen.1010974

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Peer-reviewed

Research Article

Adenylosuccinate lyase deficiency affects neurobehavior via perturbations to tyramine signaling in Caenorhabditis elegans

Corinna A. Moro,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliation Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America

https://orcid.org/0009-0008-8112-6620

⨯
Sabrina A. Sony,

Roles Conceptualization, Investigation

Affiliation Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America

https://orcid.org/0009-0005-8469-8454

⨯
Latisha P. Franklin,

Roles Investigation

Affiliation Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America
⨯
Shirley Dong,

Roles Investigation

Current address: Kelonia Therapeutics, Boston, Massachusetts, United States of America

Affiliation Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America
⨯
Mia M. Peifer,

Roles Investigation

Affiliation Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America
⨯
Kathryn E. Wittig,

Roles Investigation

Affiliation Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America
⨯
Wendy Hanna-Rose

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: wxh21@psu.edu

Affiliation Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America

https://orcid.org/0000-0002-5566-4758

⨯

Adenylosuccinate lyase deficiency affects neurobehavior via perturbations to tyramine signaling in Caenorhabditis elegans

Corinna A. Moro,
Sabrina A. Sony,
Latisha P. Franklin,
Shirley Dong,
Mia M. Peifer,
Kathryn E. Wittig,
Wendy Hanna-Rose

Published: September 29, 2023
https://doi.org/10.1371/journal.pgen.1010974

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