Neurodevelopmental deficits and cell-type-specific transcriptomic perturbations in a mouse model of HNRNPU haploinsufficiency

• Sarah A. Dugger ,

  Contributed equally to this work with: Sarah A. Dugger, Ryan S. Dhindsa

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: sad2175@cumc.columbia.edu (SAD); Ryan.Dhindsa@bcm.edu (RSD)

  Affiliations Institute for Genomic Medicine, Columbia University Irving Medical Center, New York, New York, United States of America, Department of Genetics and Development, Columbia University Irving Medical Center, New York, New York, United States of America

  https://orcid.org/0000-0002-8005-6754

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• Ryan S. Dhindsa ,

  Contributed equally to this work with: Sarah A. Dugger, Ryan S. Dhindsa

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Resources, Software, Visualization, Writing – review & editing

  * E-mail: sad2175@cumc.columbia.edu (SAD); Ryan.Dhindsa@bcm.edu (RSD)

  Affiliations Institute for Genomic Medicine, Columbia University Irving Medical Center, New York, New York, United States of America, Department of Pathology & Immunology, Baylor College of Medicine, Houston, Texas, United States of America, Jan and Dan Duncan Neurological Research Institute of Texas Children’s Hospital, Houston, Texas, United States of America

  https://orcid.org/0000-0002-8965-0813

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• Gabriela De Almeida Sampaio,

  Roles Investigation

  Affiliation Institute for Genomic Medicine, Columbia University Irving Medical Center, New York, New York, United States of America

  https://orcid.org/0000-0002-9955-258X

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• Andrew K. Ressler,

  Roles Investigation

  Affiliation Institute for Genomic Medicine, Columbia University Irving Medical Center, New York, New York, United States of America

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• Elizabeth E. Rafikian,

  Roles Investigation

  Affiliation Mouse Neurobehavioral Core Facility, Columbia University Irving Medical Center, New York, New York, United States of America

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• Sabrina Petri,

  Roles Investigation

  Affiliation Institute for Genomic Medicine, Columbia University Irving Medical Center, New York, New York, United States of America

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• Verity A. Letts,

  Roles Investigation

  Affiliation Institute for Genomic Medicine, Columbia University Irving Medical Center, New York, New York, United States of America

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• JiaJie Teoh,

  Roles Formal analysis, Investigation, Writing – review & editing

  Affiliation Institute for Genomic Medicine, Columbia University Irving Medical Center, New York, New York, United States of America

  https://orcid.org/0000-0001-7100-5763

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• Junqiang Ye,

  Roles Formal analysis, Investigation, Writing – review & editing

  Affiliations Department of Biochemistry and Molecular Biophysics, Columbia University Irving Medical Center, New York, New York, United States of America, Zuckerman Mind Brain and Behavior Institute, Columbia University, New York, New York, United States of America

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• Sophie Colombo,

  Roles Conceptualization, Methodology, Writing – review & editing

  Affiliation Institute for Genomic Medicine, Columbia University Irving Medical Center, New York, New York, United States of America

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• Yueqing Peng,

  Roles Formal analysis, Investigation, Methodology, Visualization, Writing – review & editing

  Affiliations Institute for Genomic Medicine, Columbia University Irving Medical Center, New York, New York, United States of America, Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York, United States of America

  https://orcid.org/0000-0002-3488-0670

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• Mu Yang,

  Roles Formal analysis, Investigation, Methodology, Resources, Visualization, Writing – review & editing

  Affiliation Mouse Neurobehavioral Core Facility, Columbia University Irving Medical Center, New York, New York, United States of America

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• Michael J. Boland,

  Roles Conceptualization, Supervision, Writing – review & editing

  Affiliations Institute for Genomic Medicine, Columbia University Irving Medical Center, New York, New York, United States of America, Department of Neurology, Columbia University Irving Medical Center, New York, New York, United States of America

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• Wayne N. Frankel,

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Supervision, Writing – review & editing

  Affiliations Institute for Genomic Medicine, Columbia University Irving Medical Center, New York, New York, United States of America, Department of Genetics and Development, Columbia University Irving Medical Center, New York, New York, United States of America

  https://orcid.org/0000-0003-2241-5314

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• David B. Goldstein

  Roles Conceptualization, Funding acquisition, Methodology, Resources, Supervision, Writing – review & editing

  Affiliations Institute for Genomic Medicine, Columbia University Irving Medical Center, New York, New York, United States of America, Department of Genetics and Development, Columbia University Irving Medical Center, New York, New York, United States of America

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