Saturation genome editing of 11 codons and exon 13 of BRCA2 coupled with chemotherapeutic drug response accurately determines pathogenicity of variants

• Sounak Sahu,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Validation, Visualization, Writing – original draft

  Affiliation Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, United States of America

  https://orcid.org/0000-0001-7290-6651

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• Teresa L. Sullivan,

  Roles Data curation, Methodology, Writing – review & editing

  Affiliation Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, United States of America

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• Alexander Y. Mitrophanov,

  Roles Data curation, Formal analysis, Methodology, Software, Validation, Writing – review & editing

  Affiliation Statistical Consulting and Scientific Programming, Frederick National Laboratory for Cancer Research, National Institutes of Health, Frederick, Maryland, United States of America

  https://orcid.org/0000-0002-9019-4034

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• Mélissa Galloux,

  Roles Data curation, Formal analysis, Methodology, Software, Validation, Writing – review & editing

  Affiliation Independent bioinformatician, Marseille, France

  https://orcid.org/0009-0009-4424-6815

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• Darryl Nousome,

  Roles Data curation, Formal analysis, Software, Writing – review & editing

  Affiliation CCR Bioinformatics Resource, Leidos Biomedical Sciences, Inc. Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America

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• Eileen Southon,

  Roles Data curation, Methodology, Writing – review & editing

  Affiliation Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, United States of America

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• Dylan Caylor,

  Roles Data curation, Methodology, Writing – review & editing

  Affiliation Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, United States of America

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• Arun Prakash Mishra,

  Roles Data curation, Methodology, Writing – review & editing

  Affiliation Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, United States of America

  https://orcid.org/0000-0001-6558-1166

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• Christine N. Evans,

  Roles Methodology, Resources, Writing – review & editing

  Affiliation Genome Modification Core, Laboratory Animal Sciences Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America

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• Michelle E. Clapp,

  Roles Methodology, Resources, Writing – review & editing

  Affiliation Genome Modification Core, Laboratory Animal Sciences Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America

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• Sandra Burkett,

  Roles Data curation, Methodology, Writing – review & editing

  Affiliation Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, United States of America

  https://orcid.org/0000-0002-5476-4028

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• Tyler Malys,

  Roles Formal analysis, Methodology, Supervision, Writing – review & editing

  Affiliation Statistical Consulting and Scientific Programming, Frederick National Laboratory for Cancer Research, National Institutes of Health, Frederick, Maryland, United States of America

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• Raj Chari,

  Roles Methodology, Resources, Writing – review & editing

  Affiliation Genome Modification Core, Laboratory Animal Sciences Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America

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• Kajal Biswas,

  Roles Conceptualization, Data curation, Methodology, Writing – review & editing

  Current address: Division of Cancer Prevention, National Cancer Institute, Bethesda, Maryland, United States of America

  Affiliation Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, United States of America

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• Shyam K. Sharan

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Supervision, Writing – original draft

  * E-mail: sharans@mail.nih.gov

  Affiliation Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, United States of America

  https://orcid.org/0000-0002-9333-870X

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