MYC disrupts transcriptional and metabolic circadian oscillations in cancer and promotes enhanced biosynthesis

• Juliana Cazarin ,

  Contributed equally to this work with: Juliana Cazarin, Rachel E. DeRollo

  Roles Conceptualization, Formal analysis, Investigation, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America

  https://orcid.org/0000-0002-5728-1857

  ⨯
• Rachel E. DeRollo ,

  Contributed equally to this work with: Juliana Cazarin, Rachel E. DeRollo

  Roles Formal analysis, Investigation, Methodology, Project administration, Software, Validation, Visualization

  Affiliation Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America

  ⨯
• Siti Noor Ain Binti Ahmad Shahidan,

  Roles Investigation

  Affiliation Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America

  ⨯
• Jamison B. Burchett,

  Roles Conceptualization, Formal analysis, Investigation, Software, Visualization, Writing – review & editing

  Affiliation Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America

  https://orcid.org/0000-0003-4612-1310

  ⨯
• Daniel Mwangi,

  Roles Data curation, Investigation, Software

  Affiliation Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America

  ⨯
• Saikumari Krishnaiah,

  Roles Data curation, Investigation, Software, Validation, Visualization

  Affiliations Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Institute of Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Chronobiology and Sleep Institute, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

  ⨯
• Annie L. Hsieh,

  Roles Formal analysis, Investigation, Methodology

  Affiliation The Wistar Institute, Philadelphia, Pennsylvania, United States of America

  https://orcid.org/0000-0002-2048-7333

  ⨯
• Zandra E. Walton,

  Roles Funding acquisition, Investigation, Writing – review & editing

  Affiliation The Wistar Institute, Philadelphia, Pennsylvania, United States of America

  https://orcid.org/0000-0002-0465-0153

  ⨯
• Rebekah Brooks,

  Roles Formal analysis, Funding acquisition, Investigation, Software, Visualization, Writing – review & editing

  Affiliation The Wistar Institute, Philadelphia, Pennsylvania, United States of America

  ⨯
• Stephano S. Mello,

  Roles Software, Writing – review & editing

  Affiliations Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America, Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, New York, United States of America

  https://orcid.org/0000-0002-2484-086X

  ⨯
• Aalim M. Weljie ,

  Roles Conceptualization, Data curation, Funding acquisition, Methodology, Project administration, Resources, Software, Supervision, Validation, Writing – review & editing

  * E-mail: aalim@pennmedicine.upenn.edu (AMW); cvdang@jhmi.edu (CVD); Brian_Altman@urmc.rochester.edu (BJA)

  Affiliations Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Institute of Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Chronobiology and Sleep Institute, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

  ⨯
• Chi V. Dang ,

  Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

  * E-mail: aalim@pennmedicine.upenn.edu (AMW); cvdang@jhmi.edu (CVD); Brian_Altman@urmc.rochester.edu (BJA)

  Affiliations Ludwig Institute for Cancer Research, New York, New York, United States of America, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Maryland, United States of America

  ⨯
• Brian J. Altman

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: aalim@pennmedicine.upenn.edu (AMW); cvdang@jhmi.edu (CVD); Brian_Altman@urmc.rochester.edu (BJA)

  Affiliations Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America, Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, New York, United States of America

  https://orcid.org/0000-0002-3954-4916

  ⨯