UBQLN1 deficiency mediates telomere shortening and IPF through interacting with RPA1

Haoxian Zhou; Chen Xie; Yujie Xie; Yunru He; Yanlian Chen; Canfeng Zhang; Yan Zhang; Yong Zhao; Haiying Liu

doi:10.1371/journal.pgen.1010856

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Open Access

Peer-reviewed

Research Article

UBQLN1 deficiency mediates telomere shortening and IPF through interacting with RPA1

Haoxian Zhou,

Roles Conceptualization, Data curation, Investigation, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

Affiliations MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, China, Department of Cardiology, Guangdong Provincial Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China
⨯
Chen Xie,

Roles Funding acquisition, Investigation, Resources

Affiliation Cardiovascular Department, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China
⨯
Yujie Xie,

Roles Data curation, Investigation

Affiliation MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, China
⨯
Yunru He,

Roles Data curation, Investigation

Affiliation Center for Translational Medicine, Precision Medicine Institute, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
⨯
Yanlian Chen,

Roles Data curation, Funding acquisition

Affiliation Cardiovascular Department, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China
⨯
Canfeng Zhang,

Roles Data curation

Affiliation Center for Translational Medicine, Precision Medicine Institute, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
⨯
Yan Zhang,

Roles Data curation, Resources

Affiliation MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, China
⨯
Yong Zhao †,

† Deceased.

Roles Conceptualization, Data curation, Funding acquisition, Resources, Supervision

Affiliation MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, China
⨯
Haiying Liu

Roles Conceptualization, Data curation, Funding acquisition, Resources, Supervision, Writing – original draft, Writing – review & editing

* E-mail: liuhy5@mail.sysu.edu.cn

Affiliation MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, China

https://orcid.org/0000-0002-0173-3375

⨯

UBQLN1 deficiency mediates telomere shortening and IPF through interacting with RPA1

Haoxian Zhou,
Chen Xie,
Yujie Xie,
Yunru He,
Yanlian Chen,
Canfeng Zhang,
Yan Zhang,
Yong Zhao,
Haiying Liu

Published: July 18, 2023
https://doi.org/10.1371/journal.pgen.1010856

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Telomeres
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DNA replication
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Pulmonary fibrosis
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Transfection
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HeLa cells
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DNA damage
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Small interfering RNA
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Telomere length
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