Template switching between the leading and lagging strands at replication forks generates inverted copy number variants through hairpin-capped extrachromosomal DNA

• Rebecca Martin ,

  Roles Data curation, Formal analysis, Investigation, Methodology, Resources, Supervision, Validation, Visualization, Writing – review & editing

  ¶‡ These authors share first authorship on this work.

  Affiliation Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America

  https://orcid.org/0000-0002-0498-3329

  ⨯
• Claudia Y. Espinoza ,

  Roles Conceptualization, Investigation, Methodology, Resources, Writing – review & editing

  ¶‡ These authors share first authorship on this work.

  Affiliation Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America

  https://orcid.org/0000-0002-3004-8115

  ⨯
• Christopher R. L. Large,

  Roles Data curation

  Affiliation Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America

  https://orcid.org/0000-0002-5732-970X

  ⨯
• Joshua Rosswork,

  Roles Investigation

  Affiliation Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America

  ⨯
• Cole Van Bruinisse,

  Roles Investigation

  Affiliation Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America

  ⨯
• Aaron W. Miller,

  Roles Data curation, Investigation, Methodology, Resources

  Affiliation Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America

  https://orcid.org/0000-0001-5037-9539

  ⨯
• Joseph C. Sanchez,

  Roles Resources

  Affiliation Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America

  https://orcid.org/0000-0002-2444-1834

  ⨯
• Madison Miller,

  Roles Investigation

  Affiliation Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America

  ⨯
• Samantha Paskvan,

  Roles Investigation

  Affiliation Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America

  ⨯
• Gina M. Alvino,

  Roles Investigation, Supervision

  Affiliation Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America

  https://orcid.org/0000-0002-1305-2155

  ⨯
• Maitreya J. Dunham,

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – review & editing

  Affiliation Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America

  https://orcid.org/0000-0001-9944-2666

  ⨯
• M. K. Raghuraman,

  Roles Conceptualization, Funding acquisition, Investigation, Project administration, Resources, Supervision, Writing – review & editing

  Affiliation Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America

  https://orcid.org/0000-0003-2382-3707

  ⨯
• Bonita J. Brewer

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: bbrewer@uw.edu

  Affiliation Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America

  https://orcid.org/0000-0001-8782-0471

  ⨯