Combined genome-wide association study of 136 quantitative ear morphology traits in multiple populations reveal 8 novel loci

• Yi Li ,

  Contributed equally to this work with: Yi Li, Ziyi Xiong, Manfei Zhang, Pirro G. Hysi, Yu Qian, Kaustubh Adhikari

  Roles Data curation, Formal analysis, Investigation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations CAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, China, CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, China

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• Ziyi Xiong ,

  Contributed equally to this work with: Yi Li, Ziyi Xiong, Manfei Zhang, Pirro G. Hysi, Yu Qian, Kaustubh Adhikari

  Roles Data curation, Formal analysis, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Department of Genetic Identification, Erasmus MC, University Medical Center, the Netherlands, Department of Epidemiology, Erasmus MC, University Medical Center, the Netherlands

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• Manfei Zhang ,

  Contributed equally to this work with: Yi Li, Ziyi Xiong, Manfei Zhang, Pirro G. Hysi, Yu Qian, Kaustubh Adhikari

  Roles Data curation, Formal analysis, Funding acquisition, Writing – original draft, Writing – review & editing

  Affiliations CAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, China, Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China, State Key Laboratory of Genetic Engineering, Human Phenome Institute, Zhangjiang Fudan International Innovation Center, Fudan University, China

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• Pirro G. Hysi ,

  Contributed equally to this work with: Yi Li, Ziyi Xiong, Manfei Zhang, Pirro G. Hysi, Yu Qian, Kaustubh Adhikari

  Roles Data curation, Formal analysis, Writing – review & editing

  Affiliation Department of Twin Research and Genetic Epidemiology, King’s College London, United Kingdom

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• Yu Qian ,

  Contributed equally to this work with: Yi Li, Ziyi Xiong, Manfei Zhang, Pirro G. Hysi, Yu Qian, Kaustubh Adhikari

  Roles Data curation, Formal analysis, Investigation, Writing – review & editing

  Affiliations CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, China, Beijing No.8 High School, Beijing, China

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• Kaustubh Adhikari ,

  Contributed equally to this work with: Yi Li, Ziyi Xiong, Manfei Zhang, Pirro G. Hysi, Yu Qian, Kaustubh Adhikari

  Roles Data curation, Formal analysis, Writing – review & editing

  Affiliations Department of Genetics, Evolution and Environment, and UCL Genetics Institute, University College London, United Kingdom, School of Mathematics and Statistics, Faculty of Science, Technology, Engineering and Mathematics, The Open University, United Kingdom

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• Jun Weng,

  Roles Data curation, Writing – review & editing

  Affiliation Center for Biometrics and Security Research & National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, China

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• Sijie Wu,

  Roles Data curation, Writing – review & editing

  Affiliations CAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, China, State Key Laboratory of Genetic Engineering, Human Phenome Institute, Zhangjiang Fudan International Innovation Center, Fudan University, China, Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, China

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• Siyuan Du,

  Roles Data curation, Writing – review & editing

  Affiliations CAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, China, Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China, University of Chinese Academy of Sciences, China

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• Rolando Gonzalez-Jose,

  Roles Data curation, Writing – review & editing

  Affiliation Instituto Patagonico de Ciencias Sociales y Humanas, Centro Nacional Patagonico, CONICET, Argentina

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• Lavinia Schuler-Faccini,

  Roles Data curation, Writing – review & editing

  Affiliation Departamento de Genetica, Universidade Federal do Rio Grande do Sul, Brasil

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• Maria-Catira Bortolini,

  Roles Data curation, Writing – review & editing

  Affiliation Departamento de Genetica, Universidade Federal do Rio Grande do Sul, Brasil

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• Victor Acuna-Alonzo,

  Roles Data curation, Writing – review & editing

  Affiliation Molecular Genetics Laboratory, National School of Anthropology and History, Mexico

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• Samuel Canizales-Quinteros,

  Roles Data curation, Writing – review & editing

  Affiliation Unidad de Genomica de Poblaciones Aplicada a la Salud, Facultad de Quimica, UNAM-Instituto Nacional de Medicina Genomica, Mexico

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• Carla Gallo,

  Roles Data curation, Writing – review & editing

  Affiliation Laboratorios de Investigacion y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Peru

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• Giovanni Poletti,

  Roles Data curation, Writing – review & editing

  Affiliation Laboratorios de Investigacion y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Peru

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• Gabriel Bedoya †,

  † Deceased.

  Roles Data curation, Writing – review & editing

  Affiliation GENMOL (Genetica Molecular), Universidad de Antioquia, Medellin, Colombia

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• Francisco Rothhammer,

  Roles Data curation, Writing – review & editing

  Affiliation Instituto de Alta Investigacion, Universidad de Tarapaca, Chile

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• Jiucun Wang,

  Roles Data curation, Writing – review & editing

  Affiliations State Key Laboratory of Genetic Engineering, Human Phenome Institute, Zhangjiang Fudan International Innovation Center, Fudan University, China, Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, China

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• Jingze Tan,

  Roles Data curation, Writing – review & editing

  Affiliation Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, China

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• Ziyu Yuan,

  Roles Data curation, Writing – review & editing

  Affiliation Fudan-Taizhou Institute of Health Sciences, China

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• Li Jin,

  Roles Data curation, Funding acquisition, Writing – review & editing

  Affiliations CAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, China, State Key Laboratory of Genetic Engineering, Human Phenome Institute, Zhangjiang Fudan International Innovation Center, Fudan University, China, Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, China, Fudan-Taizhou Institute of Health Sciences, China

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• André G. Uitterlinden,

  Roles Data curation, Writing – review & editing

  Affiliations Department of Epidemiology, Erasmus MC, University Medical Center, the Netherlands, Department of Internal Medicine, Erasmus MC, University Medical Center, the Netherlands

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• Mohsen Ghanbari,

  Roles Data curation, Writing – review & editing

  Affiliation Department of Epidemiology, Erasmus MC, University Medical Center, the Netherlands

  ⨯
• M. Arfan Ikram,

  Roles Data curation, Writing – review & editing

  Affiliation Department of Epidemiology, Erasmus MC, University Medical Center, the Netherlands

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• Tamar Nijsten,

  Roles Data curation, Writing – review & editing

  Affiliation Department of Dermatology, Erasmus MC, University Medical Center, the Netherlands

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• Xiangyu Zhu,

  Roles Data curation, Writing – review & editing

  Affiliations Center for Biometrics and Security Research & National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, China, School of Artificial Intelligence, University of Chinese Academy of Sciences, China

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• Zhen Lei,

  Roles Data curation, Writing – review & editing

  Affiliations Center for Biometrics and Security Research & National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, China, School of Artificial Intelligence, University of Chinese Academy of Sciences, China

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• Peilin Jia,

  Roles Funding acquisition, Writing – review & editing

  Affiliation CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, China

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• Andres Ruiz-Linares ,

  Roles Funding acquisition, Supervision, Writing – review & editing

  ¶‡ AR-L, TDS, SW, MK and FL also contributed equally to this work.

  Affiliations Department of Genetics, Evolution and Environment, and UCL Genetics Institute, University College London, United Kingdom, Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, China, Aix-Marseille Universite, CNRS, EFS, ADES, France

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• Timothy D. Spector ,

  Roles Supervision, Writing – review & editing

  ¶‡ AR-L, TDS, SW, MK and FL also contributed equally to this work.

  Affiliation Department of Twin Research and Genetic Epidemiology, King’s College London, United Kingdom

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• Sijia Wang ,

  Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

  * E-mail: wangsijia@picb.ac.cn (SW); f.liu@erasmusmc.nl (FL)

  ¶‡ AR-L, TDS, SW, MK and FL also contributed equally to this work.

  Affiliations CAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, China, Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, China

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• Manfred Kayser ,

  Roles Conceptualization, Supervision, Writing – original draft, Writing – review & editing

  ¶‡ AR-L, TDS, SW, MK and FL also contributed equally to this work.

  Affiliation Department of Genetic Identification, Erasmus MC, University Medical Center, the Netherlands

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•  [ ... ],
• Fan Liu

  Roles Conceptualization, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: wangsijia@picb.ac.cn (SW); f.liu@erasmusmc.nl (FL)

  ¶‡ AR-L, TDS, SW, MK and FL also contributed equally to this work.

  Affiliations CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, China, Department of Genetic Identification, Erasmus MC, University Medical Center, the Netherlands

  https://orcid.org/0000-0001-9241-8161

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