Chromatin landscape, DSB levels, and cKU-70/80 contribute to patterning of meiotic DSB processing along chromosomes in C. elegans

Laura I. Lascarez-Lagunas; Marina Martinez-Garcia; Saravanapriah Nadarajan; Brianna N. Diaz-Pacheco; Elizaveta Berson; Mónica P. Colaiácovo

doi:10.1371/journal.pgen.1010627

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Open Access

Peer-reviewed

Research Article

Chromatin landscape, DSB levels, and cKU-70/80 contribute to patterning of meiotic DSB processing along chromosomes in C. elegans

Laura I. Lascarez-Lagunas ,

Contributed equally to this work with: Laura I. Lascarez-Lagunas, Marina Martinez-Garcia

Roles Conceptualization, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

Affiliation Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, United States of America

https://orcid.org/0000-0002-6362-1651

⨯
Marina Martinez-Garcia ,

Contributed equally to this work with: Laura I. Lascarez-Lagunas, Marina Martinez-Garcia

Roles Conceptualization, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

Current address: Department of Biotechnology-Plant Biology, School of Agricultural, Food and Biosystems Engineering, Universidad Politécnica de Madrid, Madrid, Spain

Affiliation Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, United States of America

https://orcid.org/0000-0001-8491-2557

⨯
Saravanapriah Nadarajan,

Roles Formal analysis, Investigation

Affiliation Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, United States of America

https://orcid.org/0000-0001-5273-4514

⨯
Brianna N. Diaz-Pacheco,

Roles Formal analysis, Investigation

Affiliation Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, United States of America

https://orcid.org/0000-0001-9014-1234

⨯
Elizaveta Berson,

Roles Investigation, Validation

Affiliation Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Mónica P. Colaiácovo

Roles Conceptualization, Funding acquisition, Project administration, Writing – original draft, Writing – review & editing

* E-mail: mcolaiacovo@genetics.med.harvard.edu

Affiliation Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, United States of America

https://orcid.org/0000-0001-7803-4372

⨯

Chromatin landscape, DSB levels, and cKU-70/80 contribute to patterning of meiotic DSB processing along chromosomes in C. elegans

Laura I. Lascarez-Lagunas,
Marina Martinez-Garcia,
Saravanapriah Nadarajan,
Brianna N. Diaz-Pacheco,
Elizaveta Berson,
Mónica P. Colaiácovo

Published: January 27, 2023
https://doi.org/10.1371/journal.pgen.1010627

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