Multi-omic association study identifies DNA methylation-mediated genotype and smoking exposure effects on lung function in children living in urban settings

• Matthew Dapas ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: mdapas@uchicago.edu (DM); c-ober@genetics.uchicago.edu (OC)

  Affiliation Department of Human Genetics, University of Chicago, Chicago Illinois, United States of America

  https://orcid.org/0000-0002-8004-8535

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• Emma E. Thompson,

  Roles Data curation, Formal analysis

  Affiliation Department of Human Genetics, University of Chicago, Chicago Illinois, United States of America

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• William Wentworth-Sheilds,

  Roles Data curation, Project administration

  Affiliation Department of Human Genetics, University of Chicago, Chicago Illinois, United States of America

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• Selene Clay,

  Roles Formal analysis

  Affiliation Department of Human Genetics, University of Chicago, Chicago Illinois, United States of America

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• Cynthia M. Visness,

  Roles Data curation, Project administration, Supervision

  Affiliation Rho Inc., Durham, North Carolina, United States of America

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• Agustin Calatroni,

  Roles Data curation, Formal analysis

  Affiliation Rho Inc., Durham, North Carolina, United States of America

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• Joanne E. Sordillo,

  Roles Formal analysis, Validation

  Affiliation Department of Population Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

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• Diane R. Gold,

  Roles Validation

  Affiliations Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America, Channing Division of Network Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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• Robert A. Wood,

  Roles Investigation

  Affiliation Department of Pediatrics, Johns Hopkins University Medical Center, Baltimore, Maryland, United States of America

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• Melanie Makhija,

  Roles Investigation

  Affiliation Division of Allergy and Immunology, Ann & Robert H. Lurie Children’s Hospital, Chicago, Illinois, United States of America

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• Gurjit K. Khurana Hershey,

  Roles Investigation

  Affiliations Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America, Division of Asthma Research, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States of America

  https://orcid.org/0000-0001-6663-977X

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• Michael G. Sherenian,

  Roles Investigation

  Affiliations Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America, Division of Asthma Research, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States of America

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• Rebecca S. Gruchalla,

  Roles Investigation

  Affiliation Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

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• Michelle A. Gill,

  Roles Investigation

  Affiliation Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, United States of America

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• Andrew H. Liu,

  Roles Investigation

  Affiliation Department of Allergy and Immunology, Children’s Hospital Colorado, University of Colorado School of Medicine, Aurora, Colorado, United States of America

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• Haejin Kim,

  Roles Investigation

  Affiliation Department of Medicine, Henry Ford Health System, Detroit, Michigan, United States of America

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• Meyer Kattan,

  Roles Investigation

  Affiliation Columbia University College of Physicians and Surgeons, New York, New York, United States of America

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• Leonard B. Bacharier,

  Roles Project administration, Supervision

  Affiliation Monroe Carell Jr. Children’s Hospital at Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

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• Deepa Rastogi,

  Roles Investigation

  Affiliation Children’s National Health System, Washington, District of Columbia, United States of America

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• Matthew C. Altman,

  Roles Formal analysis

  Affiliation Department of Allergy and Infectious Diseases, University of Washington, Seattle, Washington, United States of America

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• William W. Busse,

  Roles Conceptualization, Funding acquisition, Project administration, Supervision

  Affiliation Department of Pediatrics and Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America

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• Patrice M. Becker,

  Roles Project administration, Supervision

  Affiliation National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, United States of America

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• Dan Nicolae,

  Roles Methodology, Supervision

  Affiliation Department of Statistics, University of Chicago, Chicago, Illinois, United States of America

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• George T. O’Connor,

  Roles Investigation, Project administration, Supervision, Writing – review & editing

  Affiliation Pulmonary Center, Boston University School of Medicine, Boston, Massachusetts, United States of America

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• James E. Gern,

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

  Affiliation Department of Pediatrics and Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America

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• Daniel J. Jackson,

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

  Affiliation Department of Pediatrics and Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America

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•  [ ... ],
• Carole Ober

  Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

  * E-mail: mdapas@uchicago.edu (DM); c-ober@genetics.uchicago.edu (OC)

  Affiliation Department of Human Genetics, University of Chicago, Chicago Illinois, United States of America

  https://orcid.org/0000-0003-4626-9809

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