Gene burden analysis identifies genes associated with increased risk and severity of adult-onset hearing loss in a diverse hospital-based cohort

• Daniel Hui,

  Roles Conceptualization, Data curation, Formal analysis, Writing – original draft, Writing – review & editing

  Affiliation Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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• Shadi Mehrabi,

  Roles Conceptualization, Data curation, Formal analysis

  Affiliation Department of Otolaryngology, University of Michigan, Ann Arbor, Michigan, United States of America

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• Alexandra E. Quimby,

  Roles Data curation, Formal analysis

  Affiliation Department of Otolaryngology–Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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• Tingfang Chen,

  Roles Data curation, Formal analysis

  Affiliation Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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• Sixing Chen,

  Roles Data curation, Formal analysis

  Affiliation Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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• Joseph Park,

  Roles Data curation, Formal analysis

  Affiliation Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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• Binglan Li,

  Roles Data curation, Formal analysis

  Affiliation Department of Biomedical Data Science, Stanford University, Stanford, California, United States of America

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• Regeneron Genetics Center,

  Affiliation Regeneron Genetics Center, Tarrytown, New York, United States of America

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• Penn Medicine Biobank ,

  ¶‡ A full list of contributors is available in S1 Note.

  Affiliation Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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• Michael J. Ruckenstein,

  Roles Conceptualization, Supervision

  Affiliation Department of Otolaryngology–Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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• Daniel J. Rader,

  Roles Conceptualization, Project administration, Supervision

  Affiliations Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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• Marylyn D. Ritchie,

  Roles Conceptualization, Project administration, Supervision

  Affiliations Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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• Jason A. Brant,

  Roles Conceptualization, Data curation, Supervision

  Affiliations Department of Otolaryngology–Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Otolaryngology–Head and Neck Surgery, Corporal Michael J. Crescenz VAMC, Philadelphia, Pennsylvania, United States of America

  https://orcid.org/0000-0002-3492-0679

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• Douglas J. Epstein ,

  Contributed equally to this work with: Douglas J. Epstein, Iain Mathieson

  Roles Conceptualization, Formal analysis, Project administration, Supervision, Writing – review & editing

  * E-mail: epsteind@pennmedicine.upenn.edu (DJE); mathi@pennmedicine.upenn.edu (IM)

  Affiliation Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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• Iain Mathieson

  Contributed equally to this work with: Douglas J. Epstein, Iain Mathieson

  Roles Conceptualization, Formal analysis, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: epsteind@pennmedicine.upenn.edu (DJE); mathi@pennmedicine.upenn.edu (IM)

  Affiliation Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

  https://orcid.org/0000-0002-4256-3982

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