ESR1 gene amplification and MAP3K mutations are selected during adjuvant endocrine therapies in relapsing Hormone Receptor-positive, HER2-negative breast cancer (HR+ HER2- BC)

• Lorenzo Ferrando ,

  Contributed equally to this work with: Lorenzo Ferrando, Andrea Vingiani, Anna Garuti

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation IRCCS Ospedale Policlinico San Martino, Genova, Italy

  https://orcid.org/0000-0002-4025-7930

  ⨯
• Andrea Vingiani ,

  Contributed equally to this work with: Lorenzo Ferrando, Andrea Vingiani, Anna Garuti

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

  Affiliations Department of Pathology and Laboratory Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy, Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy

  https://orcid.org/0000-0002-9827-3976

  ⨯
• Anna Garuti ,

  Contributed equally to this work with: Lorenzo Ferrando, Andrea Vingiani, Anna Garuti

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

  Affiliation IRCCS Ospedale Policlinico San Martino, Genova, Italy

  ⨯
• Claudio Vernieri,

  Roles Data curation, Formal analysis, Investigation, Supervision, Validation, Writing – original draft, Writing – review & editing

  Affiliations Department of Oncology and Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy, IFOM, The FIRC Institute of Molecular Oncology, Milan, Italy

  ⨯
• Antonino Belfiore,

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Department of Pathology and Laboratory Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy

  ⨯
• Luca Agnelli,

  Roles Data curation, Formal analysis, Investigation, Methodology, Resources, Software, Writing – original draft, Writing – review & editing

  Affiliation Department of Pathology and Laboratory Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy

  https://orcid.org/0000-0003-0582-6170

  ⨯
• Gianpaolo Dagrada,

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Department of Pathology and Laboratory Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy

  ⨯
• Diana Ivanoiu,

  Roles Data curation, Formal analysis, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Department of Surgery and Cancer, Imperial College London, London, United Kingdom

  ⨯
• Giuseppina Bonizzi,

  Roles Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Department of Pathology, IEO European Institute of Oncology IRCCS, Milan, Italy

  ⨯
• Elisabetta Munzone,

  Roles Investigation, Methodology, Project administration, Supervision, Validation, Writing – original draft, Writing – review & editing

  Affiliation Division of Medical Senology, IEO European Institute of Oncology IRCCS, Milan, Italy

  ⨯
• Luana Lippolis,

  Roles Investigation, Methodology, Resources, Validation, Visualization

  Affiliation Division of Pathology, Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico, Milan, Italy

  ⨯
• Martina Dameri,

  Roles Data curation, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

  Affiliation Department of Internal Medicine (DiMI), University of Genoa, Genova, Italy

  ⨯
• Francesco Ravera,

  Roles Data curation, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

  Affiliation Department of Internal Medicine (DiMI), University of Genoa, Genova, Italy

  https://orcid.org/0000-0002-1619-1708

  ⨯
• Marco Colleoni,

  Roles Conceptualization, Data curation, Investigation, Methodology, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Division of Medical Senology, IEO European Institute of Oncology IRCCS, Milan, Italy

  ⨯
• Giuseppe Viale,

  Roles Conceptualization, Data curation, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

  Affiliations Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy, Department of Pathology, IEO European Institute of Oncology IRCCS, Milan, Italy

  ⨯
• Luca Magnani,

  Roles Data curation, Formal analysis, Investigation, Methodology, Software, Supervision, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Surgery and Cancer, Imperial College London, London, United Kingdom

  ⨯
• Alberto Ballestrero,

  Roles Data curation, Investigation, Supervision, Validation, Writing – original draft, Writing – review & editing

  Affiliations IRCCS Ospedale Policlinico San Martino, Genova, Italy, Department of Internal Medicine (DiMI), University of Genoa, Genova, Italy

  ⨯
• Gabriele Zoppoli ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  ¶‡ These Authors contributed equally to the present manuscript.

  Affiliations IRCCS Ospedale Policlinico San Martino, Genova, Italy, Department of Internal Medicine (DiMI), University of Genoa, Genova, Italy

  ⨯
•  [ ... ],
• Giancarlo Pruneri

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: giancarlo.pruneri@istitutotumori.mi.it

  ¶‡ These Authors contributed equally to the present manuscript.

  Affiliations Department of Pathology and Laboratory Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy, Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy

  https://orcid.org/0000-0002-7963-7172

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