Leveraging pleiotropy to discover and interpret GWAS results for sleep-associated traits

• Sung Chun ,

  Contributed equally to this work with: Sung Chun, Sebastian Akle, Chris Cotsapas, Shamil R. Sunyaev

  Roles Conceptualization, Formal analysis, Writing – original draft, Writing – review & editing

  Affiliations Division of Genetics, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America, Division of Pulmonary Medicine, Boston Children’s Hospital, Boston, Massachusetts, United States of America, Altius Institute for Biomedical Sciences, Seattle, Washington, United States of America, Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, United States of America

  https://orcid.org/0000-0003-3440-1913

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• Sebastian Akle ,

  Contributed equally to this work with: Sung Chun, Sebastian Akle, Chris Cotsapas, Shamil R. Sunyaev

  Roles Conceptualization, Formal analysis, Writing – original draft, Writing – review & editing

  Affiliations Division of Genetics, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America, Altius Institute for Biomedical Sciences, Seattle, Washington, United States of America, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts, United States of America

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• Athanasios Teodosiadis,

  Roles Formal analysis, Writing – review & editing

  Affiliation Altius Institute for Biomedical Sciences, Seattle, Washington, United States of America

  https://orcid.org/0000-0002-5419-3536

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• Brian E. Cade,

  Roles Resources, Writing – review & editing

  Affiliations Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America, Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts, United States of America, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

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• Heming Wang,

  Roles Resources, Writing – review & editing

  Affiliations Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America, Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts, United States of America, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

  https://orcid.org/0000-0002-1486-7495

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• Tamar Sofer,

  Roles Resources, Writing – review & editing

  Affiliations Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

  https://orcid.org/0000-0001-8520-8860

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• Daniel S. Evans,

  Roles Resources, Writing – review & editing

  Affiliation California Pacific Medical Center Research Institute, San Francisco, California, United States of America

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• Katie L. Stone,

  Roles Resources, Writing – review & editing

  Affiliation California Pacific Medical Center Research Institute, San Francisco, California, United States of America

  https://orcid.org/0000-0003-2797-3171

  ⨯
• Sina A. Gharib,

  Roles Resources, Writing – review & editing

  Affiliations Division of Pulmonary, Critical Care, and Sleep Medicine, University of Washington, Seattle, Washington, United States of America, Computational Medicine Core at Center for Lung Biology, University of Washington, Seattle, Washington, United States of America

  https://orcid.org/0000-0002-2480-4367

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• Sutapa Mukherjee,

  Roles Resources, Writing – review & editing

  Affiliations Respiratory and Sleep Services, Southern Adelaide Local Health Network, Adelaide, South Australia, Australia, Adelaide Institute for Sleep Health, Flinders University, Adelaide, South Australia, Australia

  https://orcid.org/0000-0001-5021-1648

  ⨯
• Lyle J. Palmer,

  Roles Resources, Writing – review & editing

  Affiliation School of Public Health, University of Adelaide, Adelaide, South Australia, Australia

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• David Hillman,

  Roles Resources, Writing – review & editing

  Affiliations Centre for Sleep Science, University of Western Australia, Perth, Australia, Department of Pulmonary Physiology and Sleep Medicine, Sir Charles Gairdner Hospital, Perth, Australia

  https://orcid.org/0000-0001-9987-539X

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• Jerome I. Rotter,

  Roles Resources, Writing – review & editing

  Affiliation The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California, United States of America

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• Craig L. Hanis,

  Roles Resources, Writing – review & editing

  Affiliation Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, Texas, United States of America

  https://orcid.org/0000-0002-4880-5348

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• John A. Stamatoyannopoulos,

  Roles Resources, Writing – review & editing

  Affiliations Altius Institute for Biomedical Sciences, Seattle, Washington, United States of America, Departments of Medicine and Genome Sciences, University of Washington, Seattle, Washington, United States of America

  ⨯
• Susan Redline,

  Roles Conceptualization, Funding acquisition, Resources, Writing – review & editing

  Affiliations Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America, Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts, United States of America, Division of Pulmonary, Critical Care, and Sleep Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America

  https://orcid.org/0000-0002-6585-1610

  ⨯
• Chris Cotsapas ,

  Contributed equally to this work with: Sung Chun, Sebastian Akle, Chris Cotsapas, Shamil R. Sunyaev

  Roles Conceptualization, Writing – original draft, Writing – review & editing

  * E-mail: cotsapas@broadinstitute.org (CC); ssunyaev@hms.harvard.edu (SRS)

  Affiliations Altius Institute for Biomedical Sciences, Seattle, Washington, United States of America, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America, Department of Neurology, Yale School of Medicine, New Haven, Connecticut, United States of America, Department of Genetics, Yale School of Medicine, New Haven, Connecticut, United States of America

  https://orcid.org/0000-0002-7772-5910

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•  [ ... ],
• Shamil R. Sunyaev

  Contributed equally to this work with: Sung Chun, Sebastian Akle, Chris Cotsapas, Shamil R. Sunyaev

  Roles Conceptualization, Funding acquisition, Writing – original draft, Writing – review & editing

  * E-mail: cotsapas@broadinstitute.org (CC); ssunyaev@hms.harvard.edu (SRS)

  Affiliations Division of Genetics, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America, Altius Institute for Biomedical Sciences, Seattle, Washington, United States of America, Department of Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, United States of America

  https://orcid.org/0000-0001-5715-5677

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