Yeast-based evolutionary modeling of androgen receptor mutations and natural selection

Haoran Zhang; Lu Zhang; Shaoyong Chen; Mingdong Yao; Zhenyi Ma; Yingjin Yuan

doi:10.1371/journal.pgen.1010518

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Open Access

Peer-reviewed

Research Article

Yeast-based evolutionary modeling of androgen receptor mutations and natural selection

Haoran Zhang ,

Contributed equally to this work with: Haoran Zhang, Lu Zhang

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations Frontier Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin, People’s Republic of China, School of Chemical Engineering and Technology, Tianjin University, Tianjin, People’s Republic of China
⨯
Lu Zhang ,

Contributed equally to this work with: Haoran Zhang, Lu Zhang

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology

Affiliations Frontier Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin, People’s Republic of China, School of Chemical Engineering and Technology, Tianjin University, Tianjin, People’s Republic of China
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Shaoyong Chen,

Roles Writing – original draft, Writing – review & editing

Affiliation Hematology-Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America
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Mingdong Yao,

Roles Formal analysis, Methodology

Affiliations Frontier Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin, People’s Republic of China, School of Chemical Engineering and Technology, Tianjin University, Tianjin, People’s Republic of China
⨯
Zhenyi Ma,

Roles Resources

Affiliation School of Basic Medical Sciences, Tianjin Medical University, Tianjin, People’s Republic of China
⨯
Yingjin Yuan

Roles Conceptualization, Funding acquisition, Supervision

* E-mail: yjyuan@tju.edu.cn

Affiliations Frontier Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin, People’s Republic of China, School of Chemical Engineering and Technology, Tianjin University, Tianjin, People’s Republic of China

https://orcid.org/0000-0003-0553-0089

⨯

Yeast-based evolutionary modeling of androgen receptor mutations and natural selection

Haoran Zhang,
Lu Zhang,
Shaoyong Chen,
Mingdong Yao,
Zhenyi Ma,
Yingjin Yuan

Published: December 2, 2022
https://doi.org/10.1371/journal.pgen.1010518

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Yeast
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Prostate cancer
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